Artículo
Polyunsaturated ω3 fatty acids prevent the cardiac hypertrophy in hypertensive rats
Zavala, Maite Raquel
; Longarzo, Mria Lucrecia
; Vazquez, Romina Florencia
; Velez Rueda, Jorge Omar
; Maté, Sabina María
; Villa-Abrille, María Celeste
Fecha de publicación:
02/2023
Editorial:
Elsevier Science
Revista:
Biochimica et Biophysica Acta - General Subjects
ISSN:
0304-4165
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
It has been demonstrated that supplementation with the two main omega 3 polyunsaturated fatty acids (ω3 FAs), docosahexaenoic acid (DHA), and eicosapentaenoic acid (EPA), leads to modifications in the cardiac physiology. ω3 FAs can affect the membrane's lipid composition, as well as proteins' location and/or function. The Na+/H+ exchanger (NHE1) is an integral membrane protein involved in the maintenance of intracellular pH and its hyperactivity has been associated with the development of various cardiovascular diseases such as cardiac hypertrophy. Our aim was to determine the effect of ω3 FAs on systolic blood pressure (SBP), lipid profiles, NHE1 activity, and cardiac function in spontaneously hypertensive rats (SHR) using Wistar rats (W) as normotensive control. After weaning, the rats received orally ω3 FAs (200 mg/kg body mass/day/ 4 months). We measured SBP, lipid profiles, and different echocardiography parameters, which were used to calculate cardiac hypertrophy index, systolic function, and ventricular geometry. The rats were sacrificed, and ventricular cardiomyocytes were obtained to measure NHE1 activity. While the treatment with ω3 FAs did not affect the SBP, lipid analysis of plasma revealed a significant decrease in omega-6/omega-3 ratio, correlated with a significant reduction in left ventricular mass index in SHR. The NHE1 activity was significantly higher in SHR compared with W. While in W the NHE1 activity was similar in both groups, a significant decrease in NHE1 activity was detected in SHRs supplemented with ω3 FAs, reaching values comparable with W. Altogether, these findings revealed that diet supplementation with ω3 FAs since early age prevents the development of cardiac hypertrophy in SHR, perhaps by decreasing NHE1 activity, without altering hemodynamic overload.
Palabras clave:
CARDIAC HYPERTROPHY
,
DHA
,
EPA
,
NHE1
,
OMEGA 3 POLYUNSATURATED FATTY ACIDS
,
SHR
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Articulos(CIC)
Articulos de CENTRO DE INVEST.CARDIOVASCULARES (I)
Articulos de CENTRO DE INVEST.CARDIOVASCULARES (I)
Articulos(INIBIOLP)
Articulos de INST.DE INVEST.BIOQUIMICAS DE LA PLATA
Articulos de INST.DE INVEST.BIOQUIMICAS DE LA PLATA
Citación
Zavala, Maite Raquel; Longarzo, Mria Lucrecia; Vazquez, Romina Florencia; Velez Rueda, Jorge Omar; Maté, Sabina María; et al.; Polyunsaturated ω3 fatty acids prevent the cardiac hypertrophy in hypertensive rats; Elsevier Science; Biochimica et Biophysica Acta - General Subjects; 1867; 2; 2-2023; 1-8
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