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dc.contributor.author
Samouillan, Valerie
dc.contributor.author
Garcia, Eduardo
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Benitez Amaro, Aleyda
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La Chica Lhoëst, Maria Teresa
dc.contributor.author
Dandurand, Jany
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Actis Dato, Virginia
dc.contributor.author
Guerra, Jose Maria
dc.contributor.author
Escolà Gil, Joan Carles
dc.contributor.author
Chiabrando, Gustavo Alberto
dc.contributor.author
Enrich, Carlos
dc.contributor.author
Llorente-Cortes, Vicenta
dc.date.available
2024-02-14T15:47:49Z
dc.date.issued
2023-04
dc.identifier.citation
Samouillan, Valerie; Garcia, Eduardo; Benitez Amaro, Aleyda; La Chica Lhoëst, Maria Teresa; Dandurand, Jany; et al.; Inhibitory Effects of LRP1-Based Immunotherapy on Cardiac Extracellular Matrix Biophysical Alterations Induced by Hypercholesterolemia; American Chemical Society; Journal of Medicinal Chemistry; 66; 9; 4-2023; 6251-6262
dc.identifier.issn
0022-2623
dc.identifier.uri
http://hdl.handle.net/11336/226896
dc.description.abstract
The accumulation of lipids in cardiomyocytes contributes to cardiac dysfunction. The specific blockage of cardiomyocyte cholesteryl ester (CE) loading by antibodies (Abs) against the P3 sequence (Gly1127–Cys1140) of the LRP1 receptor improves cardiac insulin sensitivity. The impact of anti-P3 Abs on high-fat diet (HFD)-induced cardiac extracellular matrix (ECM) biophysical alterations was analyzed. Both IrP (without Abs) and P3-immunized rabbits (with Abs) were randomized into groups fed either HFD or a standard chow diet. Cardiac lipids, proteins, and carbohydrates were characterized by Fourier transform infrared spectroscopy in the attenuated total reflectance mode. The hydric organization and physical structure were determined by differential scanning calorimetry. HFD increased the levels of esterified lipids, collagen, and α-helical structures and upregulated fibrosis, bound water, and ECM plasticization in the heart. The inhibitory effect of anti-P3 Abs on cardiac CE accumulation was sufficient to reduce the collagen-filled extracellular space, the level of fibrosis, and the amount of bound water but did not counteract ECM plasticization in the heart of hypercholesterolemic rabbits.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
American Chemical Society
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/
dc.subject
EXTRACELLULAR MATRIX
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CHOLESTEROL
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IMMUNOTHERAPY
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HEART
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Bioquímica y Biología Molecular
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Inhibitory Effects of LRP1-Based Immunotherapy on Cardiac Extracellular Matrix Biophysical Alterations Induced by Hypercholesterolemia
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2024-02-14T11:40:01Z
dc.journal.volume
66
dc.journal.number
9
dc.journal.pagination
6251-6262
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Washington
dc.description.fil
Fil: Samouillan, Valerie. Université de Toulouse; Francia. Université Paul Sabatier; Francia
dc.description.fil
Fil: Garcia, Eduardo. Universitat Autònoma de Barcelona; España. Instituto de Investigaciones Biomedicas de Barcelona; España. Consejo Superior de Investigaciones Científicas; España
dc.description.fil
Fil: Benitez Amaro, Aleyda. Universitat Autònoma de Barcelona; España. Instituto de Investigaciones Biomedicas de Barcelona; España. Consejo Superior de Investigaciones Científicas; España
dc.description.fil
Fil: La Chica Lhoëst, Maria Teresa. Universitat Autònoma de Barcelona; España. Université Paul Sabatier; Francia. Instituto de Investigaciones Biomedicas de Barcelona; España
dc.description.fil
Fil: Dandurand, Jany. Université de Toulouse; Francia. Université Paul Sabatier; Francia
dc.description.fil
Fil: Actis Dato, Virginia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Córdoba; Argentina
dc.description.fil
Fil: Guerra, Jose Maria. Universitat Autònoma de Barcelona; España
dc.description.fil
Fil: Escolà Gil, Joan Carles. Institut Dinvestigació Biomèdica Sant Pau; España. Metabolic Basis of Cardiovascular Risk, Biomedical Research Institute Sant Pau; España
dc.description.fil
Fil: Chiabrando, Gustavo Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina
dc.description.fil
Fil: Enrich, Carlos. Universidad de Barcelona; España
dc.description.fil
Fil: Llorente-Cortes, Vicenta. Centro de Investigación En Red En Enfermedades Cardiovasculares; España. Instituto de Investigaciones Biomedicas de Barcelona; España. Universitat Autònoma de Barcelona; España. Consejo Superior de Investigaciones Científicas; España
dc.journal.title
Journal of Medicinal Chemistry
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://pubs.acs.org/doi/10.1021/acs.jmedchem.2c02103
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1021/acs.jmedchem.2c02103
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