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dc.contributor.author
Gano, Anny
dc.contributor.author
Barney, Thaddeus M.
dc.contributor.author
Vore, Andrew S.
dc.contributor.author
Mondello, Jamie E.
dc.contributor.author
Varlinskaya, Elena I.
dc.contributor.author
Pautassi, Ricardo Marcos
dc.contributor.author
Deak, Terrence
dc.date.available
2024-02-14T15:11:44Z
dc.date.issued
2023-12
dc.identifier.citation
Gano, Anny; Barney, Thaddeus M.; Vore, Andrew S.; Mondello, Jamie E.; Varlinskaya, Elena I.; et al.; Cues associated with a single ethanol exposure elicit conditioned corticosterone responses in adolescent male but not female Sprague–Dawley rats; John Wiley & Sons; Developmental Psychobiology; 66; 1; 12-2023; 1-14
dc.identifier.issn
0012-1630
dc.identifier.uri
http://hdl.handle.net/11336/226878
dc.description.abstract
It has been shown that ethanol-induced interleukin-6 (IL-6) in adult male Sprague–Dawley rats was sensitized by environmental stimuli paired with ethanol and was accompanied by a conditioned increase in corticosterone (CORT). Adolescent males showed ethanol-induced IL-6 conditioning more readily than adults. The present studies examined whether female adolescents display IL-6 conditioning and whether adolescents of either sex show CORT conditioning. Male and female (N = 212, n = 6–10) adolescent (postnatal day 33–40) rats were given ethanol (2 g/kg intraperitoneal injection; the unconditioned stimulus), either paired with a lavender-scented novel context (the conditioned stimulus) or explicitly unpaired from context. Rats were tested in the context without ethanol and brains/blood were collected. Adolescent females did not show signs of neuroimmune (Experiment 1) or CORT conditioning (Experiments 2–4). Paired males showed enhanced CORT to the scented context relative to unpaired counterparts when the interoceptive cue of a saline injection was used on test day (Experiment 2). Experiment 5 used a delayed conditioning procedure and showed that male paired adolescents showed significantly higher CORT in response to context, showing that classically conditioned CORT response was precipitated by environmental cues alone. These findings indicate that adolescent males may be predisposed to form conditioned associations between alcohol and environmental cues, contributing to adolescent vulnerability to long-lasting ethanol effects.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
John Wiley & Sons
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
ADOLESCENCE
dc.subject
CONDITIONING
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CORTICOSTERONE
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CTA
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HPA AXIS
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IL-6
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SEX DIFFERENCES
dc.subject.classification
Drogadicción
dc.subject.classification
Ciencias de la Salud
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Cues associated with a single ethanol exposure elicit conditioned corticosterone responses in adolescent male but not female Sprague–Dawley rats
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2024-02-14T11:45:42Z
dc.journal.volume
66
dc.journal.number
1
dc.journal.pagination
1-14
dc.journal.pais
Estados Unidos
dc.description.fil
Fil: Gano, Anny. University Of Binghamton. Departament Of Psychology; Estados Unidos
dc.description.fil
Fil: Barney, Thaddeus M.. University Of Binghamton. Departament Of Psychology; Estados Unidos
dc.description.fil
Fil: Vore, Andrew S.. University Of Binghamton. Departament Of Psychology; Estados Unidos
dc.description.fil
Fil: Mondello, Jamie E.. University Of Binghamton. Departament Of Psychology; Estados Unidos
dc.description.fil
Fil: Varlinskaya, Elena I.. University Of Binghamton. Departament Of Psychology; Estados Unidos
dc.description.fil
Fil: Pautassi, Ricardo Marcos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina
dc.description.fil
Fil: Deak, Terrence. University Of Binghamton. Departament Of Psychology; Estados Unidos
dc.journal.title
Developmental Psychobiology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/10.1002/dev.22442
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1002/dev.22442
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