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Artículo

Enantioselective uptake and translocation of atenolol in higher plants

Podio, Natalia SoledadIcon ; Sun, Chengliang; Dudley, Stacia; Gan, Jay
Fecha de publicación: 12/2023
Editorial: Elsevier
Revista: Science of the Total Environment
ISSN: 0048-9697
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Química Analítica

Resumen

The presence of pharmaceuticals in surface water and wastewater has been an increasing area of research since they can represent a possible route for human exposure when these waters are used to irrigate crops. The concentration of these drugs in crops depends on their uptake and translocation within plants. A less recognized question is that over 50 % of pharmaceuticals are chiral compounds, but there is little knowledge about their enantioselectivity in plants. In this study, we evaluated the uptake, bioconcentration, and translocation of enantiomers of atenolol, a commonly used beta-blocker, in Arabidopsis thaliana cells and Lactuca sativa plants under hydroponic conditions. Atenolol was taken up by Arabidopsis thaliana cells during 120 h of exposure to solutions with 1 mg/L of R/S-(±)-atenolol. A moderate preference for R-(+)-atenolol over S-(−)-atenolol was observed, with the enantiomeric fraction (EF) reaching 0.532 ± 0.002 for the R enantiomer. Atenolol was also taken up and translocated by Lactuca sativa after hydroponic cultivation in nutrient solutions containing 1 or 10 μg/L R/S-(±)-atenolol. Moderate enantioselectivity was detected in the treatment with 10 μg/L, and the EF after 168 h was 0.42 ± 0.01, suggesting that S-(−)-atenolol was preferentially accumulated. Selectivity was also observed in the translocation factor (TF), calculated as the ratio of the concentration in the leaves over that in the roots. As many emerging contaminants are chiral, our findings highlight the importance to consider their fate and risks in terrestrial ecosystems at the enantiomer scale.
Palabras clave: ATENOLOL , CHIRAL COMPOUNDS , CHIRAL SELECTIVITY , EMERGING CONTAMINANTS , ENANTIOSELECTIVITY , PPCPS
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info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/226870
DOI: http://dx.doi.org/10.1016/j.scitotenv.2023.166720
Colecciones
Articulos(ICYTAC)
Articulos de INST. DE CIENCIA Y TECNOLOGIA DE ALIMENTOS CORDOBA
Citación
Podio, Natalia Soledad; Sun, Chengliang; Dudley, Stacia; Gan, Jay; Enantioselective uptake and translocation of atenolol in higher plants; Elsevier; Science of the Total Environment; 904; 12-2023; 1-8
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