Artículo
The epigenetic EZH2/H3K27ME3 axis modulates lactotroph tumour cell prolife
Zlocoswki, Natacha; Sosa, Liliana del Valle
; de la Cruz Thea, Benjamín Isaías
; Guido, Carolina Beatriz
; Martín, Mauricio Gerardo
; Mukdsi, Jorge Humberto; Torres, Alicia Ines
; Petiti, Juan Pablo
Fecha de publicación:
03/2023
Editorial:
BioScientifica
Revista:
Journal of Endocrinology
ISSN:
0022-0795
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Interest in epigenetics has gained substantial momentum as a result of their identified role in the regulation of tumor progression as well as their ability to pharmacologically target genes. Pituitary neuroendocrine tumors (PitNETs) tend to be inactivated via epigenetic modification, and although emerging evidence has suggested a role for epigenetic factors in PitNET tumorigenesis, the degree to which these factors may be targeted by new therapeutic strategies still remains poorly understood. The objective of the present study was to examine the participation of the EZH2/H3K27me3 axis in the proliferation of lactotroph tumor cells. We demonstrated that the levels of EZH2 and H3K27me3 were increased in murine experimental prolactin (PRL) tumors with respect to a control pituitary, in contrast with the low p21 mRNA levels encountered, with an H3K27me3 enrichment being observed in its promoter region in a GH3 tumor cell. Furthermore, specific EZH2/H3K27me3 axis inhibition blocked the proliferation of primary tumor cell culture and GH3 cells, thereby making it an attractive therapeutic target for PRL PitNETs.
Palabras clave:
EZH2
,
GSK343
,
H3K27ME3
,
PRL TUMOR
Archivos asociados
Licencia
Identificadores
Colecciones
Articulos(INICSA)
Articulos de INSTITUTO DE INVESTIGACIONES EN CIENCIAS DE LA SALUD
Articulos de INSTITUTO DE INVESTIGACIONES EN CIENCIAS DE LA SALUD
Articulos(INIMEC - CONICET)
Articulos de INSTITUTO DE INV. MEDICAS MERCEDES Y MARTIN FERREYRA
Articulos de INSTITUTO DE INV. MEDICAS MERCEDES Y MARTIN FERREYRA
Citación
Zlocoswki, Natacha; Sosa, Liliana del Valle; de la Cruz Thea, Benjamín Isaías; Guido, Carolina Beatriz; Martín, Mauricio Gerardo; et al.; The epigenetic EZH2/H3K27ME3 axis modulates lactotroph tumour cell prolife; BioScientifica; Journal of Endocrinology; 257; 2; 3-2023; 1-13
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