Artículo
Environmentally relevant DEHP exposure during gestational and lactational period inhibits filamin a testicular expression
Pérez, Pablo Aníbal
; Toledo, Jonathan
; Vitellini, Facundo; Cuello, Victoria Navall; Cantarelli, Verónica Inés
; Ponzio, Marina Flavia
; Mukdsi, Jorge Humberto; Gutiérrez, Silvina





Fecha de publicación:
10/2023
Editorial:
Springer
Revista:
Journal of Molecular Histology
ISSN:
1567-2379
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Toxicological studies have revealed that DEHP exposure during pregnancy may induce developmental disorders, especially in male offspring, leading to morphological and functional alterations in the reproductive system by mechanisms that should be investigated. Thus, the aim of this work was to analyze the testicular toxicity induced by an environmentally relevant DEHP dose during development and its impact on FLNA, a protein that participates in the blood-testis barrier assembly. We used male Wistar rats exposed to DEHP during pregnancy and lactation. The results showed that DEHP exposure during development and lactation increased body weight, decreased gonadal weight and shortened anogenital distance. This phthalate induced morphological changes in the testis, suggestive of hypospermatogenesis. DEHP exposure decreased the number of FLNA positive cells and the expression of FLNA and claudin-1 in prepubertal testes. Furthermore, DEHP inhibited FLNA and claudin-1 protein expression in adult male rats. These results indicated that exposure to DEHP during gestation and lactation perturbed testis development and suggested that FLNA is a target protein of DEHP, possibly contributing to the phthalate-induced damage on BTB.
Palabras clave:
ENDOCRINE DISRUPTOR
,
IN UTERO
,
MALE REPRODUCTION
,
PHTHALATES
,
TESTIS
,
TOXICITY
Archivos asociados
Licencia
Identificadores
Colecciones
Articulos(INICSA)
Articulos de INSTITUTO DE INVESTIGACIONES EN CIENCIAS DE LA SALUD
Articulos de INSTITUTO DE INVESTIGACIONES EN CIENCIAS DE LA SALUD
Citación
Pérez, Pablo Aníbal; Toledo, Jonathan; Vitellini, Facundo; Cuello, Victoria Navall; Cantarelli, Verónica Inés; et al.; Environmentally relevant DEHP exposure during gestational and lactational period inhibits filamin a testicular expression; Springer; Journal of Molecular Histology; 54; 5; 10-2023; 509-520
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