Artículo
Sulfobutylether-β-cyclodextrin: A functional biopolymer for drug delivery applications
Pardeshi, Chandrakantsing V.; Kothawade, Rucha V.; Markad, Ashwini R.; Pardeshi, Sagar R.; Kulkarni, Abhijeet D.; Chaudhari, Prashant J.; Longhi, Marcela Raquel
; Dhas, Namdev; Naik, Jitendra B.; Surana, Sanjay J.; García, Mónica Cristina
Fecha de publicación:
02/2023
Editorial:
Elsevier
Revista:
Carbohydrate Polymers
ISSN:
0144-8617
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Sulfobutylether β-cyclodextrin (SBE-β-CD) is a polyanionic cyclic oligosaccharide that contains glucopyranose units forming a torus ring-like structure. SBE-β-CD is gifted with many favorable properties viz. relatively high solubility (>50 folds compared to β-CD), improved stability, and biocompatibility that praised SBE-β-CD as a smart polymer for drug delivery applications. Commercially, SBE-β-CD is popular by its brand name Captisol®. The present review discusses the structure, properties, and preparation methods of SBE-β-CD-based inclusion complexes (ICs). Furthermore, we discuss here the preparation and applications of SBE-β-CD ICs-based nanoparticulate drug delivery systems, which combines the merits of both, ICs (enhanced solubility) and nanoparticles (NPs, targeted therapy). Patents on and FDA-approved Captisol®-enabled products are tabulated in the benefit of readers. The toxicological aspects and current clinical status of SBE-β-CD or SBE-β-CD-based products are briefly explained in the present review. In our opinion, the present review would be a pathfinder to allow dissemination of information on SBE-β-CD.
Palabras clave:
ACETIC ACID (176)
,
BUTYL SULTONE (14747178)
,
CANCER
,
CAPTISOL
,
CAPTISOL (91886200)
,
CHITIN (6857375)
,
CHITOSAN (71853)
,
DRUG DELIVERY
,
GLYCOL CHITOSAN (155819511)
,
INCLUSION COMPLEX
,
NANOPARTICLES
,
POLOXAMER 407 (24751)
,
POLYETHYLENE GLYCOL 400 (91975)
,
SULFOBUTYLETHER Β-CYCLODEXTRIN (146157717)
,
SULFOBUTYLETHER-Β-CYCLODEXTRIN
,
TMPYP (135398505)
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Colecciones
Articulos(UNITEFA)
Articulos de UNIDAD DE INVESTIGACION Y DESARROLLO EN TECNOLOGIA FARMACEUTICA
Articulos de UNIDAD DE INVESTIGACION Y DESARROLLO EN TECNOLOGIA FARMACEUTICA
Citación
Pardeshi, Chandrakantsing V.; Kothawade, Rucha V.; Markad, Ashwini R.; Pardeshi, Sagar R.; Kulkarni, Abhijeet D.; et al.; Sulfobutylether-β-cyclodextrin: A functional biopolymer for drug delivery applications; Elsevier; Carbohydrate Polymers; 301; 2-2023; 1-19
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