Mostrar el registro sencillo del ítem
dc.contributor.author
Park, Junghoon
dc.contributor.author
Giudicatti, Axel Joel
dc.contributor.author
Bader, Zein Eddin
dc.contributor.author
Han, Min Kyun
dc.contributor.author
Møller, Christian
dc.contributor.author
Arce, Agustín Lucas
dc.contributor.author
Xu, Zheng-Yi
dc.contributor.author
Yang, Seong Wook
dc.contributor.author
Manavella, Pablo Andrés
dc.contributor.author
Yun, Dae-Jin
dc.date.available
2024-02-14T11:39:11Z
dc.date.issued
2023-05
dc.identifier.citation
Park, Junghoon; Giudicatti, Axel Joel; Bader, Zein Eddin; Han, Min Kyun; Møller, Christian; et al.; The high expression of osmotically responsive gene15–histone deacetylase9 complex associates with hyponastic leaves 1 to modulate microRNA expression in response to abscisic acid signaling; American Society of Plant Biologist; Plant Cell; 35; 8; 5-2023; 2910-2928
dc.identifier.issn
1040-4651
dc.identifier.uri
http://hdl.handle.net/11336/226734
dc.description.abstract
The regulation of microRNA (miRNA) biogenesis is crucial for maintaining plant homeostasis under biotic and abiotic stress. The crosstalk between the RNA polymerase II (Pol-II) complex and the miRNA processing machinery has emerged as a central hub modulating transcription and cotranscriptional processing of primary miRNA transcripts (pri-miRNAs). However, it remains unclear how miRNA-specific transcriptional regulators recognize MIRNA loci. Here, we show that the Arabidopsis (Arabidopsis thaliana) HIGH EXPRESSION OF OSMOTICALLY RESPONSIVE GENE15 (HOS15)–HISTONE DEACETYLASE9 (HDA9) complex is a conditional suppressor of miRNA biogenesis, particularly in response to abscisic acid (ABA). When treated with ABA, hos15/hda9 mutants show enhanced transcription of pri-miRNAs that is accompanied by increased processing, leading to overaccumulation of a set of mature miRNAs. Moreover, upon recognition of the nascent pri-miRNAs, the ABA–induced recruitment of the HOS15–HDA9 complex to MIRNA loci is guided by HYPONASTIC LEAVES 1 (HYL1). The HYL1–dependent recruitment of the HOS15–HDA9 complex to MIRNA loci suppresses expression of MIRNAs and processing of pri-miRNA. Most importantly, our findings indicate that nascent pri-miRNAs serve as scaffolds for recruiting transcriptional regulators, specifically to MIRNA loci. This indicates that RNA molecules can act as regulators of their own expression by causing a negative feedback loop that turns off their transcription, providing a self-buffering system.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
American Society of Plant Biologist
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
ARABIDOPSIS THALIANA
dc.subject
HOS15
dc.subject
HYL1
dc.subject
MIRNA
dc.subject.classification
Bioquímica y Biología Molecular
dc.subject.classification
Ciencias Biológicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
The high expression of osmotically responsive gene15–histone deacetylase9 complex associates with hyponastic leaves 1 to modulate microRNA expression in response to abscisic acid signaling
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2024-02-02T15:52:29Z
dc.journal.volume
35
dc.journal.number
8
dc.journal.pagination
2910-2928
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Rockville
dc.description.fil
Fil: Park, Junghoon. Konkuk University; Corea del Sur
dc.description.fil
Fil: Giudicatti, Axel Joel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Agrobiotecnología del Litoral. Universidad Nacional del Litoral. Instituto de Agrobiotecnología del Litoral; Argentina
dc.description.fil
Fil: Bader, Zein Eddin. Konkuk University; Corea del Sur
dc.description.fil
Fil: Han, Min Kyun. Yonsei University; Corea del Sur
dc.description.fil
Fil: Møller, Christian. Yonsei University; Corea del Sur
dc.description.fil
Fil: Arce, Agustín Lucas. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Agrobiotecnología del Litoral. Universidad Nacional del Litoral. Instituto de Agrobiotecnología del Litoral; Argentina
dc.description.fil
Fil: Xu, Zheng-Yi. Northeast Normal University; China
dc.description.fil
Fil: Yang, Seong Wook. Yonsei University; Corea del Sur
dc.description.fil
Fil: Manavella, Pablo Andrés. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Agrobiotecnología del Litoral. Universidad Nacional del Litoral. Instituto de Agrobiotecnología del Litoral; Argentina
dc.description.fil
Fil: Yun, Dae-Jin. Konkuk University; Corea del Sur. Northeast Normal University; China
dc.journal.title
Plant Cell
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/plcell/advance-article/doi/10.1093/plcell/koad132/7169302
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1093/plcell/koad132
Archivos asociados