Mostrar el registro sencillo del ítem
dc.contributor.author
Park, Junghoon
dc.contributor.author
Giudicatti, Axel Joel
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.contributor.author
Bader, Zein Eddin
dc.contributor.author
Han, Min Kyun
dc.contributor.author
Møller, Christian
dc.contributor.author
Arce, Agustín Lucas
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.contributor.author
Xu, Zheng-Yi
dc.contributor.author
Yang, Seong Wook
dc.contributor.author
Manavella, Pablo Andrés
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.contributor.author
Yun, Dae-Jin
dc.date.available
2024-02-14T11:39:11Z
dc.date.issued
2023-05
dc.identifier.citation
Park, Junghoon; Giudicatti, Axel Joel; Bader, Zein Eddin; Han, Min Kyun; Møller, Christian; et al.; The high expression of osmotically responsive gene15–histone deacetylase9 complex associates with hyponastic leaves 1 to modulate microRNA expression in response to abscisic acid signaling; American Society of Plant Biologist; Plant Cell; 35; 8; 5-2023; 2910-2928
dc.identifier.issn
1040-4651
dc.identifier.uri
http://hdl.handle.net/11336/226734
dc.description.abstract
The regulation of microRNA (miRNA) biogenesis is crucial for maintaining plant homeostasis under biotic and abiotic stress. The crosstalk between the RNA polymerase II (Pol-II) complex and the miRNA processing machinery has emerged as a central hub modulating transcription and cotranscriptional processing of primary miRNA transcripts (pri-miRNAs). However, it remains unclear how miRNA-specific transcriptional regulators recognize MIRNA loci. Here, we show that the Arabidopsis (Arabidopsis thaliana) HIGH EXPRESSION OF OSMOTICALLY RESPONSIVE GENE15 (HOS15)–HISTONE DEACETYLASE9 (HDA9) complex is a conditional suppressor of miRNA biogenesis, particularly in response to abscisic acid (ABA). When treated with ABA, hos15/hda9 mutants show enhanced transcription of pri-miRNAs that is accompanied by increased processing, leading to overaccumulation of a set of mature miRNAs. Moreover, upon recognition of the nascent pri-miRNAs, the ABA–induced recruitment of the HOS15–HDA9 complex to MIRNA loci is guided by HYPONASTIC LEAVES 1 (HYL1). The HYL1–dependent recruitment of the HOS15–HDA9 complex to MIRNA loci suppresses expression of MIRNAs and processing of pri-miRNA. Most importantly, our findings indicate that nascent pri-miRNAs serve as scaffolds for recruiting transcriptional regulators, specifically to MIRNA loci. This indicates that RNA molecules can act as regulators of their own expression by causing a negative feedback loop that turns off their transcription, providing a self-buffering system.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
American Society of Plant Biologist
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
ARABIDOPSIS THALIANA
dc.subject
HOS15
dc.subject
HYL1
dc.subject
MIRNA
dc.subject.classification
Bioquímica y Biología Molecular
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.subject.classification
Ciencias Biológicas
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.title
The high expression of osmotically responsive gene15–histone deacetylase9 complex associates with hyponastic leaves 1 to modulate microRNA expression in response to abscisic acid signaling
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2024-02-02T15:52:29Z
dc.journal.volume
35
dc.journal.number
8
dc.journal.pagination
2910-2928
dc.journal.pais
Estados Unidos
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.journal.ciudad
Rockville
dc.description.fil
Fil: Park, Junghoon. Konkuk University; Corea del Sur
dc.description.fil
Fil: Giudicatti, Axel Joel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Agrobiotecnología del Litoral. Universidad Nacional del Litoral. Instituto de Agrobiotecnología del Litoral; Argentina
dc.description.fil
Fil: Bader, Zein Eddin. Konkuk University; Corea del Sur
dc.description.fil
Fil: Han, Min Kyun. Yonsei University; Corea del Sur
dc.description.fil
Fil: Møller, Christian. Yonsei University; Corea del Sur
dc.description.fil
Fil: Arce, Agustín Lucas. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Agrobiotecnología del Litoral. Universidad Nacional del Litoral. Instituto de Agrobiotecnología del Litoral; Argentina
dc.description.fil
Fil: Xu, Zheng-Yi. Northeast Normal University; China
dc.description.fil
Fil: Yang, Seong Wook. Yonsei University; Corea del Sur
dc.description.fil
Fil: Manavella, Pablo Andrés. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Agrobiotecnología del Litoral. Universidad Nacional del Litoral. Instituto de Agrobiotecnología del Litoral; Argentina
dc.description.fil
Fil: Yun, Dae-Jin. Konkuk University; Corea del Sur. Northeast Normal University; China
dc.journal.title
Plant Cell
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/plcell/advance-article/doi/10.1093/plcell/koad132/7169302
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1093/plcell/koad132
Archivos asociados