Artículo
Interleukin-17 signaling influences CD8+ T cell immunity and tumor progression according to the IL-17 receptor subunit expression pattern in cancer cells
Rodriguez, Constanza
; Araujo Furlan, Cintia Liliana
; Tosello Boari, Jimena
; Bossio, Sabrina Noemí
; Boccardo, Santiago
; Fozzatti, Laura
; Canale, Fernando Pablo
; Beccaria, Cristian Gabriel
; Núñez, Nicolás
; Ceschin, Danilo Guillermo
; Piaggio, Eliane; Gruppi, Adriana
; Montes, Carolina Lucia
; Acosta Rodriguez, Eva Virginia
Fecha de publicación:
10/2023
Editorial:
Taylor & Francis
Revista:
OncoImmunology
e-ISSN:
2162-402X
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
IL-17 immune responses in cancer are controversial, with both tumor-promoting and tumor-repressing effects observed. To clarify the role of IL-17 signaling in cancer progression, we used syngeneic tumor models from different tissue origins. We found that deficiencies in host IL-17RA or IL-17A/F expression had varying effects on the in vivo growth of different solid tumors including melanoma, sarcoma, lymphoma, and leukemia. In each tumor type, the absence of IL-17 led to changes in the expression of mediators associated with inflammation and metastasis in the tumor microenvironment. Furthermore, IL-17 signaling deficiencies in the hosts resulted in decreased anti-tumor CD8+ T cell immunity and caused tumor-specific changes in several lymphoid cell populations. Our findings were associated with distinct patterns of IL-17A/F cytokine and receptor subunit expression in the injected tumor cell lines. These patterns affected tumor cell responsiveness to IL-17 and downstream intracellular signaling, leading to divergent effects on cancer progression. Additionally, we identified IL-17RC as a critical determinant of the IL-17-mediated response in tumor cells and a potential biomarker for IL-17 signaling effects in tumor progression. Our study offers insight into the molecular mechanisms underlying IL-17 activities in cancer and lays the groundwork for developing personalized immunotherapies.
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Articulos(CIBICI)
Articulos de CENTRO DE INV.EN BIOQUI.CLINICA E INMUNOLOGIA
Articulos de CENTRO DE INV.EN BIOQUI.CLINICA E INMUNOLOGIA
Articulos(INIMEC - CONICET)
Articulos de INSTITUTO DE INV. MEDICAS MERCEDES Y MARTIN FERREYRA
Articulos de INSTITUTO DE INV. MEDICAS MERCEDES Y MARTIN FERREYRA
Citación
Rodriguez, Constanza; Araujo Furlan, Cintia Liliana; Tosello Boari, Jimena; Bossio, Sabrina Noemí; Boccardo, Santiago; et al.; Interleukin-17 signaling influences CD8+ T cell immunity and tumor progression according to the IL-17 receptor subunit expression pattern in cancer cells; Taylor & Francis; OncoImmunology; 12; 1; 10-2023; 1-19
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