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Artículo

Leptin receptor expression in blood mononuclear cells of lactating women is associated with infant body weight: Potential role as a molecular biomarker

Malpeli, Agustina; Fasano, Maria VictoriaIcon ; Sala, Marisa; Obregón, Pablo; Casado, Carla; Mendez, Ignacio; Fotia, Lucrecia; Castrogiovanni, Daniel CayetanoIcon ; Varea, Ana; Disalvo, Liliana; Tournier, Andrea; Mazziota, Lucía; Rocha, Daniela; Kruger, Ana LuzIcon ; Orellano, Laura; Andreoli, Maria FlorenciaIcon
Fecha de publicación: 08/2023
Editorial: John Wiley & Sons Ltd
Revista: Pediatric Obesity
ISSN: 2047-6302
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Bioquímica y Biología Molecular

Resumen

Background: Molecular biomarkers of maternal leptin resistance associated with infant weight are needed. Objectives: To evaluate gene expression of leptin receptor (LEPR), suppressor of cytokine signalling 3 (SOCS3) and insulin receptor in peripheral blood mononuclear cells (PBMCs) of lactating women and their relationship with infant body weight and adiposity. Methods: At day 10 postpartum, maternal gene expression in PBMCs as well as leptin and insulin concentrations in plasma and milk were assessed (n = 68). Infant weight and BMI z-scores, skinfolds and arm circumference were obtained at 10 days and/or at 3 months old. Results: In mothers with pre-pregnancy overweight or obesity (OW/OB), LEPR expression was reduced (p = 0.013) whereas plasma and milk leptin and milk insulin concentrations were elevated. LEPR expression was positively related with infant weight z-score (Beta (95% CI): 0.40 (0.17, 0.63), p = 0.001) but not with leptin concentrations. SOCS3 expression was positively related with infant weight z-score (Beta (95% CI): 0.28 (0.04, 0.51), p = 0.024) and arm circumference (Beta (95% CI): 0.57 (0.32, 0.82), p < 0.001). Relationships remained significant after adjusting for maternal and infant confounders. Conclusions: LEPR and SOCS3 gene expression in PBMCs are novel maternal molecular biomarkers that reflect leptin resistance and are associated with infant body weight and adiposity.
Palabras clave: BIOMARKERS , INSULIN , LACTATION , LEPTIN , PBMC
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info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/225698
URL: https://onlinelibrary.wiley.com/doi/10.1111/ijpo.13072
DOI: http://dx.doi.org/10.1111/ijpo.13072
Colecciones
Articulos(CCT - LA PLATA)
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - LA PLATA
Articulos(IMBICE)
Articulos de INST.MULTIDISCIPL.DE BIOLOGIA CELULAR (I)
Citación
Malpeli, Agustina; Fasano, Maria Victoria; Sala, Marisa; Obregón, Pablo; Casado, Carla; et al.; Leptin receptor expression in blood mononuclear cells of lactating women is associated with infant body weight: Potential role as a molecular biomarker; John Wiley & Sons Ltd; Pediatric Obesity; 18; 11; 8-2023; 1-11
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