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dc.contributor.author
Silva, Azul  
dc.contributor.author
Martínez, María Cecilia  
dc.date.available
2024-02-02T14:44:40Z  
dc.date.issued
2023-01  
dc.identifier.citation
Silva, Azul; Martínez, María Cecilia; Spatial memory deficits in Alzheimer’s disease and their connection to cognitive maps’ formation by place cells and grid cells; Frontiers Media; Frontiers in Behavioral Neuroscience; 16; 1-2023; 1-8  
dc.identifier.issn
1662-5153  
dc.identifier.uri
http://hdl.handle.net/11336/225612  
dc.description.abstract
Whenever we navigate through different contexts, we build a cognitive map: an internal representation of the territory. Spatial navigation is a complex skill that involves multiple types of information processing and integration. Place cells and grid cells, collectively with other hippocampal and medial entorhinal cortex neurons (MEC), form a neural network whose activity is critical for the representation of self-position and orientation along with spatial memory retrieval. Furthermore, this activity generates new representations adapting to changes in the environment. Though there is a normal decline in spatial memory related to aging, this is dramatically increased in pathological conditions such as Alzheimer’s disease (AD). AD is a multi-factorial neurodegenerative disorder affecting mainly the hippocampus-entorhinal cortex (HP-EC) circuit. Consequently, the initial stages of the disease have disorientation and wandering behavior as two of its hallmarks. Recent electrophysiological studies have linked spatial memory deficits to difficulties in spatial information encoding. Here we will discuss map impairment and remapping disruption in the HP-EC network, as a possible circuit mechanism involved in the spatial memory and navigation deficits observed in AD, pointing out the benefits of virtual reality as a tool for early diagnosis and rehabilitation.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Frontiers Media  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
ALZHEIMER’S DISEASE  
dc.subject
COGNITIVE MAP  
dc.subject
ENTORHINAL CORTEX  
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HIPPOCAMPUS  
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NAVIGATION  
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REMAPPING  
dc.subject.classification
Neurociencias  
dc.subject.classification
Medicina Básica  
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CIENCIAS MÉDICAS Y DE LA SALUD  
dc.title
Spatial memory deficits in Alzheimer’s disease and their connection to cognitive maps’ formation by place cells and grid cells  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2024-02-02T11:16:28Z  
dc.journal.volume
16  
dc.journal.pagination
1-8  
dc.journal.pais
Suiza  
dc.journal.ciudad
Laussane  
dc.description.fil
Fil: Silva, Azul. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Fisiología y Biofísica Bernardo Houssay. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Fisiología y Biofísica Bernardo Houssay; Argentina  
dc.description.fil
Fil: Martínez, María Cecilia. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Fisiología, Biología Molecular y Celular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Fisiología y Biofísica Bernardo Houssay. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Fisiología y Biofísica Bernardo Houssay; Argentina  
dc.journal.title
Frontiers in Behavioral Neuroscience  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fnbeh.2022.1082158/full  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3389/fnbeh.2022.1082158