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Artículo

Rats as sources of multidrug-resistant Enterobacteriaceae in animal production environments

Dominguez, Johana ElizabethIcon ; Lovera, RosarioIcon ; Sánchez, Juliana PatriciaIcon ; Redondo, Leandro MartinIcon ; Chacana, Pablo AnibalIcon ; Cavia, ReginoIcon ; Fernandez Miyakawa, Mariano EnriqueIcon
Fecha de publicación: 06/2023
Editorial: Wiley Blackwell Publishing, Inc
Revista: Zoonoses and Public Health
ISSN: 1863-1959
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Otras Ciencias Biológicas

Resumen

Rattus norvegicus and Rattus rattus are commensal pest rodents, considered reservoirs and vectors of zoonotic pathogens. In livestock farms, the wide use of antimicrobials and their release into the environment lead to high long-term residual concentrations, which may in turn lead to the occurrence of antimicrobial resistance (AMR). Farm environments serve as AMR sources, resulting in the transmission of antimicrobial-resistant bacteria and their AMR genes of livestock origin into wildlife. This study aimed to analyse the profile of enterobacteria carrying AMR determinants in rats captured in livestock farms to determine their potential vectors as for the spread of AMR. To this end, 56 rats (52 R. norvegicus and 4 R. rattus) were live-trapped on 11 farms (pig, dairy, poultry and mixed farms) located in central Argentina, from spring 2016 to autumn 2017. From 50 of the R. norvegicus individuals and three of the R. rattus individuals found in 10 of the farms, we isolated 53 Escherichia coli and five Salmonella strains. Susceptibility to antimicrobials, genotypic profiles, minimal inhibitory concentration of colistin and the presence of mcr-1 and genes encoding extended-spectrum β-lactamase (ESBL) were determined. Of the 58 isolates not susceptible to different antimicrobial classes, 28 of the E. coli strains and two of the Salmonella strains were defined as multi-drug resistant (MDR). S. Westhampton and S. Newport recovered were not susceptible to ampicillin or all the cephems tested. One of the E. coli obtained showed resistance to colistin and harboured the mcr-1 gene, demonstrated by PCR and conjugation. In two ESBL-producing Salmonella isolated from rats, CTX-M-2 genes were responsible for the observed resistance to third-generation cephalosporins. The MDR E. coli isolates showed several different resistance patterns (23), although some of them were the same in different individuals and different farms, with six resistance patterns, evidencing the dispersion of strains. These findings suggest that rats play a role in the dissemination of AMR determinants between animal, humans and environmental reservoirs.
Palabras clave: BETA-LACTAMASE CTX-M2 , COLISTIN , DRUG RESISTANCE, BACTERIAL , FARMS , LIVESTOCK , RATS
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info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/225579
URL: https://onlinelibrary.wiley.com/doi/10.1111/zph.13071
DOI: https://doi.org/10.1111/zph.13071
Colecciones
Articulos (IPVET)
Articulos de INSTITUTO DE PATOBIOLOGIA VETERINARIA
Articulos(IEGEBA)
Articulos de INSTITUTO DE ECOLOGIA, GENETICA Y EVOLUCION DE BS. AS
Articulos(SEDE CENTRAL)
Articulos de SEDE CENTRAL
Citación
Dominguez, Johana Elizabeth; Lovera, Rosario; Sánchez, Juliana Patricia; Redondo, Leandro Martin; Chacana, Pablo Anibal; et al.; Rats as sources of multidrug-resistant Enterobacteriaceae in animal production environments; Wiley Blackwell Publishing, Inc; Zoonoses and Public Health; 70; 7; 6-2023; 627-635
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