Persistent SARS-Cov-2 Infection in an Immunocompromised Host: Role of the Cellular Immune Response

We present a patient with B-cell depletion and persistence of positive SARS-CoV-2 RT-PCR along 19 weeks despite having received treatment with corticosteroids, Convalescent Plasma (CP) and remdesivir. Direct genome sequences were obtained with a pattern of substitutions characteristic of the B.1.1.7 (alpha) lineage and the presence of mutations during its viral persistence. Although specific humoral response was not detected, there was evidence of a specific cellular response that was enhanced after the first dose of the vaccine.

Palabras clave: SARS COV-2 , Variants , Vaccine , sequence , COVID-19

Ver el registro completo

Archivos asociados

Tamaño: 2.886Mb

Formato: PDF

Descargar

Licencia

Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)

Identificadores

URI: http://hdl.handle.net/11336/225574

URL: https://austinpublishinggroup.com/clinical-immunology/fulltext/ajci-v9-id1050.pd

Colecciones

Articulos(INBIRS)
Articulos de INSTITUTO DE INVESTIGACIONES BIOMEDICAS EN RETROVIRUS Y SIDA

Articulos(SEDE CENTRAL)
Articulos de SEDE CENTRAL

Citación

Duarte, Andrea Mariela; Cruces, Leonel Hernán; Nabaes Jodar, Mercedes Soledad; Goya, Stephanie; Monzani, María Cecilia; et al.; Persistent SARS-Cov-2 Infection in an Immunocompromised Host: Role of the Cellular Immune Response; Austin Publications; Austin Journal of Clinical Immunology; 9; 1050; 2-2023; 1-4