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dc.contributor.author
Petrillo, Ezequiel
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dc.date.available
2024-02-01T15:55:15Z
dc.date.issued
2023-01
dc.identifier.citation
Petrillo, Ezequiel; Don’t panic: An intron-centric guide to alternative splicing; American Society of Plant Biologist; Plant Cell; 35; 6; 1-2023; 1752-1761
dc.identifier.issn
1040-4651
dc.identifier.uri
http://hdl.handle.net/11336/225487
dc.description.abstract
This review is an attempt to establish concepts of splicing and alternative splicing giving proper relevance to introns, the key actors in this mechanism. It might also work as a guide for those who found their favorite gene undergoes alternative splicing and could benefit from gaining a theoretical framework to understand the possible impacts of this process. This is not a thorough review of all the work in the field, but rather a critical review of some of the most relevant work done to understand the underlying mechanisms of splicing and the key questions that remain unanswered such as: What is the physiological relevance of alternative splicing? What are the functions of the different outcomes? To what extent do different alternative splicing types contribute to the proteome? Intron retention is the most frequent alternative splicing event in plants and, although scientifically neglected, it is also common in animals. This is a heterogeneous type of alternative splicing that includes different subtypes with features that have distinctive consequences in the resulting transcripts. Remarkably, intron retention can be a dead end for a transcript, but it could also be a stable intermediate whose processing is resumed upon a particular signal or change in the cell status. New sequencing technologies combined with the study of intron lariats in different conditions might help to answer key questions and could help us to understand the actual relevance of introns in gene expression regulation.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
American Society of Plant Biologist
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
INTRONS
dc.subject
EXONS
dc.subject
ALTERNATIVE SPLICING
dc.subject
RETENTION
dc.subject.classification
Bioquímica y Biología Molecular
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dc.subject.classification
Ciencias Biológicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
Don’t panic: An intron-centric guide to alternative splicing
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2024-02-01T15:45:07Z
dc.journal.volume
35
dc.journal.number
6
dc.journal.pagination
1752-1761
dc.journal.pais
Estados Unidos
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dc.journal.ciudad
Rockville
dc.description.fil
Fil: Petrillo, Ezequiel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina
dc.journal.title
Plant Cell
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1093/plcell/koad009
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