Artículo
High density lipoprotein as a therapeutic target: Focus on its functionality
Rosso, Leonardo Gómez; Davico, Belen
; Lozano Chiappe, Ezequiel Silvano
; Tetzlaff, Walter Francisco
; Boero, Laura; Brites, Fernando Daniel
; Martin, Maximiliano Emanuel
Fecha de publicación:
11/2023
Editorial:
Tech Science Press
Revista:
Biocell
ISSN:
0327-9545
e-ISSN:
1667-5746
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Cardiovascular diseases (CVDs) are the leading cause of death globally. CVDs are a group of disorders of the heart and blood vessels and include coronary heart disease, cerebrovascular disease and rheumatic heart disease among other conditions. There are multiple independent risk factors for CVD, including hypertension, age, smoking, insulin resistance, elevated low-density lipoprotein cholesterol (LDL-C) levels, and triglyceride levels. LDL-C levels have traditionally been the target for therapies aimed at reducing CVD risk. High density lipoprotein (HDL) constitutes the only lipoprotein fraction with atheroprotective functions. Early HDL-targeted therapies have focused on increasing HDL-C levels. However, clinical trials have shown that raising HDL-C with niacin failed to achieve CVD reduction. A possible explanation for these findings is that these drugs could interfere with lipid metabolism and cause alterations in HDL structure and composition, leading to loss of functionality. As a result, targeting HDL-C levels would be insufficient to achieve CVD risk reduction, making HDL functionality a more desirable focus for HDL-directed therapies. There are several drugs which show the potential to improve HDL functionality. These drugs include molecules already approved for human use, such as statins and niacin, and particularly, compounds currently undergoing development such as apolipoprotein A-I mimetics and reconstituted HDL preparations. These therapies show promising potential to improve HDL functionality specifically. Future therapeutic strategies should incorporate HDL functionality as a main target of interest.
Palabras clave:
APO A-I MIMETICS
,
CHOLESTEROL EFFLUX
,
HDL
,
PARAOXONASE
,
RHDL
,
STATINS
Archivos asociados
Licencia
Identificadores
Colecciones
Articulos(OCA HOUSSAY)
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY
Citación
Rosso, Leonardo Gómez; Davico, Belen; Lozano Chiappe, Ezequiel Silvano; Tetzlaff, Walter Francisco; Boero, Laura; et al.; High density lipoprotein as a therapeutic target: Focus on its functionality; Tech Science Press; Biocell; 47; 11; 11-2023; 2361-2383
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