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dc.contributor.author
Dorfman, Verónica Berta
dc.contributor.author
Saucedo, Lucia
dc.contributor.author
Di Giorgio, Noelia Paula
dc.contributor.author
Inserra, Pablo Ignacio Felipe
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Fraunhoffer Navarro, Nicolas Alejandro
dc.contributor.author
Leopardo, Noelia Paola
dc.contributor.author
Halperin, Julia
dc.contributor.author
Lux, Victoria Adela R.
dc.contributor.author
Vitullo, Alfredo Daniel
dc.date.available
2015-10-01T16:26:38Z
dc.date.issued
2013-11-01
dc.identifier.citation
Dorfman, Verónica Berta; Saucedo, Lucia; Di Giorgio, Noelia Paula; Inserra, Pablo Ignacio Felipe; Fraunhoffer Navarro, Nicolas Alejandro; et al.; Variation in progesterone receptors and GnRH expression in the hypothalamus of the pregnant South American plains vizcacha, Lagostomus maximus (Mammalia, Rodentia); Soc Study Reproduction; Biology Of Reproduction; 89; 5; 1-11-2013; 115-115
dc.identifier.issn
0006-3363
dc.identifier.uri
http://hdl.handle.net/11336/2252
dc.description.abstract
In mammals, elevated levels of progesterone (P4) throughout gestation maintain a negative feedback over the hypothalamic-hypophyseal-gonadal (H-H-G) axis, avoiding preovulatory follicular growth and preventing ovulation. Recent studies showed that in the South American plains vizcacha (Lagostomus maximus) folliculogenesis progresses to preovulatory stages during gestation, and an ovulatory process seems to occur at midgestation. The aim of this work was to analyze hypothalamic gonadotropin-releasing hormone (GnRH) and P4 receptors (PR) expression and luteinizing hormone (LH) secretion and correlate these with the functional state of the ovary in nonovulating and ovulating females and gestating females with special emphasis in the supposedly ovulating females at midgestation. We investigated P4 and LH serum levels as well as the distribution, localization, and expression of PR and GnRH in the hypothalamus of L. maximus at different time points during gestation and in nongestating, ovulating and nonovulating, females. A significant increment in GnRH, P4, and LH was detected in midpregnant vizcachas with respect to early-pregnant and to ovulating females. PR was also significantly increased in midpregnant animals. PR was detected in neurons of the preoptic and hypothalamic areas. Coexistence of both PR and GnRH in neurons of medial preoptic area and supraoptic nucleus was detected. Midpregnant animals showed increased number of PR immunoreactive cells at median eminence, localized adjacently to GnRH immunoreactive fibers. High expression of hypothalamic GnRH and PR, despite an increased level of P4, was correlated with the presence of antral, preovulatory follicles, and luteinized unruptured follicles at midgestation that suggest a possible role of the H-H-G axis in the modulation of ovulation during gestation
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Soc Study Reproduction
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
Hypothalamus
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Ovary
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Progesterone
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Gnrh
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Vizcacha
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Gonadotropin-Releasing Hormone/Metabolism
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Biología Reproductiva
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Variation in progesterone receptors and GnRH expression in the hypothalamus of the pregnant South American plains vizcacha, Lagostomus maximus (Mammalia, Rodentia)
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-03-30 10:35:44.97925-03
dc.identifier.eissn
1529-7268
dc.journal.volume
89
dc.journal.number
5
dc.journal.pagination
115-115
dc.journal.pais
Estados Unidos de América
dc.journal.ciudad
Madison
dc.description.fil
Fil: Dorfman, Verónica Berta. Universidad Maimónides. Area de Investigaciones Biomédicas y Biotecnológicas. Centro de Estudios Biomédicos, Biotecnológicos, Ambientales y Diagnósticos; Argentina
dc.description.fil
Fil: Saucedo, Lucia. Universidad Maimónides. Area de Investigaciones Biomédicas y Biotecnológicas. Centro de Estudios Biomédicos, Biotecnológicos, Ambientales y Diagnósticos; Argentina
dc.description.fil
Fil: Di Giorgio, Noelia Paula. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina
dc.description.fil
Fil: Inserra, Pablo Ignacio Felipe. Universidad Maimónides. Area de Investigaciones Biomédicas y Biotecnológicas. Centro de Estudios Biomédicos, Biotecnológicos, Ambientales y Diagnósticos; Argentina
dc.description.fil
Fil: Fraunhoffer Navarro, Nicolas Alejandro. Universidad Maimónides. Area de Investigaciones Biomédicas y Biotecnológicas. Centro de Estudios Biomédicos, Biotecnológicos, Ambientales y Diagnósticos; Argentina
dc.description.fil
Fil: Leopardo, Noelia Paola. Universidad Maimónides. Area de Investigaciones Biomédicas y Biotecnológicas. Centro de Estudios Biomédicos, Biotecnológicos, Ambientales y Diagnósticos; Argentina
dc.description.fil
Fil: Halperin, Julia. Universidad Maimónides. Area de Investigaciones Biomédicas y Biotecnológicas. Centro de Estudios Biomédicos, Biotecnológicos, Ambientales y Diagnósticos; Argentina
dc.description.fil
Fil: Lux, Victoria Adela R.. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina
dc.description.fil
Fil: Vitullo, Alfredo Daniel. Universidad Maimónides. Area de Investigaciones Biomédicas y Biotecnológicas. Centro de Estudios Biomédicos, Biotecnológicos, Ambientales y Diagnósticos; Argentina
dc.journal.title
Biology Of Reproduction
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1095/biolreprod.113.107995
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.biolreprod.org/content/89/5/115.long


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