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dc.contributor.author
Serrano Rodríguez, Juan Manuel
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Fernández Varón, Emilio
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Cárceles Rodríguez, Carlos Mario
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San Andrés Larrea, Manuel Ignacio
dc.contributor.author
Rubio Langre, Sonia
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de la Fe, Christian
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Waxman Dova, Samanta
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Bhardwaj, Pallavi
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Sidhu, Pritam Kaur
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Litterio, Nicolas Javier
dc.contributor.author
Lorenzutti, Augusto Matías
dc.date.available
2024-01-25T14:58:54Z
dc.date.issued
2023-06
dc.identifier.citation
Serrano Rodríguez, Juan Manuel; Fernández Varón, Emilio; Cárceles Rodríguez, Carlos Mario; San Andrés Larrea, Manuel Ignacio ; Rubio Langre, Sonia; et al.; Population pharmacokinetics and pharmacokinetic/pharmacodynamic evaluation of marbofloxacin against Coagulase-negative staphylococci, Staphylococcus aureus and Mycoplasma agalactiae pathogens in goats; Elsevier; Research in Veterinary Science; 159; 6-2023; 1-10
dc.identifier.issn
0034-5288
dc.identifier.uri
http://hdl.handle.net/11336/224855
dc.description.abstract
Marbofloxacin is a broad-spectrum fluoroquinolone, and an extra-label use has been reported in horse, sheep and goat. However, extrapolation of dosage regimens from cattle to horse and small ruminants could lead to incorrect dosing due to pharmacokinetic differences among species, increasing the risk of antimicrobial resistance or toxicity. Pharmacokinetic properties of marbofloxacin, including PK/PD analysis, have been studied by intravenous, intramuscular and subcutaneous administration in lactating and non-lactating goats. A population pharmacokinetic model of marbofloxacin in goats was built using 10 pharmacokinetic studies after intravenous, intramuscular, and subcutaneous administration at a dose of 2, 5 and 10 mg/kg. Serum or plasma and milk concentration-time profiles were simultaneously fitted with a non-linear mixed effect model with Monolix software. Level of milk production (lactating and non-lactating) and health status (healthy and un-healthy) were retained as covariates on volume of distribution and clearance. Marbofloxacin concentrations were well described in plasma/serum and milk by the population model. Simulated dose regimens of marbofloxacin administered at 2, 5 and 10 mg/kg by intramuscular route for five days were evaluated (n = 5000 per group). Steady-state fAUCs for each dose regimen were obtained. Probability of target attainment of fAUC/MIC ratios were determined and PK/PDco values (highest MIC for which 90% of individuals can achieve a prior numerical value of the fAUC/MIC index) were established using Monte Carlo simulations (n = 50,000). MIC values for wild type isolates of Staphylococcus aureus, coagulase negative staphylococci, and Mycoplasma agalactiae were determined and tentative epidemiological cutoff (TECOFF) were obtained at 1.0, 0.5 and 0.5 mg/L, respectively. The PK/PDco for the dose regimen of 2 mg/kg/24 h and 5 mg/kg/24 h (0.125 and 0.25 mg/L) were lower than TECOFF (0.5 and 1 mg/L). The dosage regimen of 10 mg/kg/24 h was adequate for intermediate MIC values of 0.125–0.50 mg/L and could be effective for a population with a target fAUC/MIC ratio ˂ 48 for Coagulase negative staphylococci and Mycoplasma agalactiae, but not for Staphylococcus aureus. Results obtained in this study could be taken as a starting point by committees that set the clinical breakpoints and justifies expert rules to optimize marbofloxacin dose regimens.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
GOATS
dc.subject
MARBOFLOXACIN
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MILK
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MONTE CARLO SIMULATIONS
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POPULATION PHARMACOKINETIC
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Otras Ciencias Veterinarias
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Ciencias Veterinarias
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CIENCIAS AGRÍCOLAS
dc.title
Population pharmacokinetics and pharmacokinetic/pharmacodynamic evaluation of marbofloxacin against Coagulase-negative staphylococci, Staphylococcus aureus and Mycoplasma agalactiae pathogens in goats
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2024-01-18T15:14:59Z
dc.journal.volume
159
dc.journal.pagination
1-10
dc.journal.pais
Países Bajos
dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Serrano Rodríguez, Juan Manuel. Universidad de Córdoba; España
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Fil: Fernández Varón, Emilio. Universidad de Granada; España
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Fil: Cárceles Rodríguez, Carlos Mario. Universidad de Murcia; España
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Fil: San Andrés Larrea, Manuel Ignacio. Universidad Complutense de Madrid; España
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Fil: Rubio Langre, Sonia. Universidad Complutense de Madrid; España
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Fil: de la Fe, Christian. Universidad de Murcia; España
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Fil: Waxman Dova, Samanta. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Cátedra de Anestesiología y Algiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario; Argentina
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Fil: Bhardwaj, Pallavi. CSK Himachal Pradesh Agricultural University; India
dc.description.fil
Fil: Sidhu, Pritam Kaur. Boehringer Ingelheim Animal Health; Estados Unidos
dc.description.fil
Fil: Litterio, Nicolas Javier. Universidad Católica de Córdoba. Instituto de Investigaciones en Recursos Naturales y Sustentabilidad José Sanchez Labrador S. J. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Recursos Naturales y Sustentabilidad José Sanchez Labrador S. J.; Argentina
dc.description.fil
Fil: Lorenzutti, Augusto Matías. Universidad Católica de Córdoba. Instituto de Investigaciones en Recursos Naturales y Sustentabilidad José Sanchez Labrador S. J. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Recursos Naturales y Sustentabilidad José Sanchez Labrador S. J.; Argentina
dc.journal.title
Research in Veterinary Science
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.rvsc.2023.03.026
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0034528823000991
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