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dc.contributor.author
Korang, Steven Kwasi
dc.contributor.author
von Rohden, Elena
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Veroniki, Areti Angeliki
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Ong, Giok
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Ngalamika, Owen
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Siddiqui, Faiza
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Juul, Sophie
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Nielsen, Emil Eik
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Feinberg, Joshua Buron
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Petersen, Johanne Juul
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Legart, Christian
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Kokogho, Afoke
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Maagaard, Mathias
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Klingenberg, Sarah
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Thabane, Lehana
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Bardach, Ariel Esteban
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Ciapponi, Agustín
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Thomsen, Allan Randrup
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Jakobsen, Janus C.
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Gluud, Christian
dc.date.available
2024-01-19T14:17:34Z
dc.date.issued
2022-01
dc.identifier.citation
Korang, Steven Kwasi; von Rohden, Elena; Veroniki, Areti Angeliki; Ong, Giok; Ngalamika, Owen; et al.; Vaccines to prevent COVID-19: A living systematic review with Trial Sequential Analysis and network meta-analysis of randomized clinical trials; Public Library of Science; Plos One; 17; e0260733; 1-2022; 1-23
dc.identifier.issn
1932-6203
dc.identifier.uri
http://hdl.handle.net/11336/224283
dc.description.abstract
Background COVID-19 is rapidly spreading causing extensive burdens across the world. Effective vaccines to prevent COVID-19 are urgently needed. Methods and findings Our objective was to assess the effectiveness and safety of COVID-19 vaccines through analyses of all currently available randomized clinical trials. We searched the databases CENTRAL, MEDLINE, Embase, and other sources from inception to June 17, 2021 for randomized clinical trials assessing vaccines for COVID-19. At least two independent reviewers screened studies, extracted data, and assessed risks of bias. We conducted meta-analyses, network meta-analyses, and Trial Sequential Analyses (TSA). Our primary outcomes included all-cause mortality, vaccine efficacy, and serious adverse events. We assessed the certainty of evidence with GRADE. We identified 46 trials; 35 trials randomizing 219 864 participants could be included in our analyses. Our meta-analyses showed that mRNA vaccines (efficacy, 95% [95% confidence interval (CI), 92% to 97%]; 71 514 participants; 3 trials; moderate certainty); inactivated vaccines (efficacy, 61% [95% CI, 52% to 68%]; 48 029 participants; 3 trials; moderate certainty); protein subunit vaccines (efficacy, 77% [95% CI, -5% to 95%]; 17 737 participants; 2 trials; low certainty); and viral vector vaccines (efficacy 68% [95% CI, 61% to 74%]; 71 401 participants; 5 trials; low certainty) prevented COVID- 19. Viral vector vaccines decreased mortality (risk ratio, 0.25 [95% CI 0.09 to 0.67]; 67 563 participants; 3 trials, low certainty), but comparable data on inactivated, mRNA, and protein subunit vaccines were imprecise. None of the vaccines showed evidence of a difference on serious adverse events, but observational evidence suggested rare serious adverse events. All the vaccines increased the risk of non-serious adverse events. Conclusions The evidence suggests that all the included vaccines are effective in preventing COVID-19. The mRNA vaccines seem most effective in preventing COVID-19, but viral vector vaccines seem most effective in reducing mortality. Further trials and longer follow-up are necessary to provide better insight into the safety profile of these vaccines.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Public Library of Science
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/
dc.subject
COVID-19
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Vaccines
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Trial Sequential Analysis
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Network meta-analysis
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Epidemiología
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Ciencias de la Salud
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Vaccines to prevent COVID-19: A living systematic review with Trial Sequential Analysis and network meta-analysis of randomized clinical trials
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2024-01-17T11:14:09Z
dc.journal.volume
17
dc.journal.number
e0260733
dc.journal.pagination
1-23
dc.journal.pais
Estados Unidos
dc.journal.ciudad
San Francisco
dc.description.fil
Fil: Korang, Steven Kwasi. Copenhagen University Hospital; Dinamarca
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Fil: von Rohden, Elena. Copenhagen University Hospital; Dinamarca
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Fil: Veroniki, Areti Angeliki. Imperial College London; Reino Unido. St. Michael’s Hospital; Canadá
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Fil: Ong, Giok. John Radcliffe Hospital; Reino Unido
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Fil: Ngalamika, Owen. University of Zambia; Zambia
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Fil: Siddiqui, Faiza. Copenhagen University Hospital; Dinamarca
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Fil: Juul, Sophie. Copenhagen University Hospital; Dinamarca
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Fil: Nielsen, Emil Eik. Copenhagen University Hospital; Dinamarca
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Fil: Feinberg, Joshua Buron. Copenhagen University Hospital; Dinamarca
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Fil: Petersen, Johanne Juul. Copenhagen University Hospital; Dinamarca
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Fil: Legart, Christian. Universidad de Copenhagen; Dinamarca. Copenhagen University Hospital; Dinamarca
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Fil: Kokogho, Afoke. Henry M. Jackson Foundation Medical Research International; Nigeria
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Fil: Maagaard, Mathias. Copenhagen University Hospital; Dinamarca. Zealand University Hospital; Dinamarca
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Fil: Klingenberg, Sarah. Copenhagen University Hospital; Dinamarca
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Fil: Thabane, Lehana. Mcmaster University; Canadá
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Fil: Bardach, Ariel Esteban. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; Argentina. Instituto de Efectividad Clínica y Sanitaria; Argentina
dc.description.fil
Fil: Ciapponi, Agustín. Instituto de Efectividad Clínica y Sanitaria; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; Argentina
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Fil: Thomsen, Allan Randrup. Universidad de Copenhagen; Dinamarca
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Fil: Jakobsen, Janus C.. University of Southern Denmark; Dinamarca. Copenhagen University Hospital; Dinamarca
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Fil: Gluud, Christian. Copenhagen University Hospital; Dinamarca. University of Southern Denmark; Dinamarca
dc.journal.title
Plos One
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1371/journal.pone.0260733
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0260733
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