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dc.contributor.author
Ibarra, Juan Carlos Daniel
dc.contributor.author
Helbling, Ignacio Marcelo
dc.contributor.author
Luna, Julio Alberto
dc.date.available
2017-08-14T20:16:09Z
dc.date.issued
2014-01
dc.identifier.citation
Ibarra, Juan Carlos Daniel; Helbling, Ignacio Marcelo; Luna, Julio Alberto; Mathematical modeling of drug delivery from cylindrical implantable devices; Wiley; Mathematical Methods In The Applied Sciences; 37; 17; 1-2014; 2677-2688
dc.identifier.issn
0170-4214
dc.identifier.uri
http://hdl.handle.net/11336/22357
dc.description.abstract
A mechanistic mathematical model applicable to the controlled dispersed-drug release from cylindrical device such as implantable drug delivery system was derived. Analytical solutions based on the pseudosteady state approximation are derived taken account an exact external medium volume. The model prediction is accurate when the initial drug load is higher than the drug solubility in the polymer. The results obtained are compared with the analytical solutions available in the literature. The equations are corroborated by comparison with experimental profiles reported in the literature for sink conditions and non sink conditions. The evolution of concentration distribution profiles is compared for different volumen of external medium. A reduction in the volume of the external solution leads to an increase in the concentration on the surface of the device, which determines decreases in the release of drug. One criterion for determining whether the volume of external solution should be considered for the prediction of drug release fromcylindrical devices is established. This criterion is based on establishing amaximum percentage error allowed in the values of amount of drug released. The usefulness of the model is focused in the design of implant for controlled release of drug into a small volume of external medium of release.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Wiley
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Cylindrical Geometry
dc.subject
Partial Differential Equation
dc.subject
Controlled Release
dc.subject
Implant
dc.subject
Finite External Medium
dc.subject.classification
Otras Matemáticas
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Matemáticas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Mathematical modeling of drug delivery from cylindrical implantable devices
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-07-31T17:49:58Z
dc.journal.volume
37
dc.journal.number
17
dc.journal.pagination
2677-2688
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Hoboken
dc.description.fil
Fil: Ibarra, Juan Carlos Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina
dc.description.fil
Fil: Helbling, Ignacio Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina
dc.description.fil
Fil: Luna, Julio Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina
dc.journal.title
Mathematical Methods In The Applied Sciences
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1002/mma.3007
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1002/mma.3007/abstract
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