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dc.contributor.author
Lowet, Eric
dc.contributor.author
Sheehan, Daniel J.
dc.contributor.author
Chialva, Ulises
dc.contributor.author
De Oliveira Pena, Rodrigo
dc.contributor.author
Mount, Rebecca A.
dc.contributor.author
Xiao, Sheng
dc.contributor.author
Zhou, Samuel L.
dc.contributor.author
Tseng, Hua-an
dc.contributor.author
Gritton, Howard
dc.contributor.author
Shroff, Sanaya
dc.contributor.author
Kondabolu, Krishnakanth
dc.contributor.author
Cheung, Cyrus
dc.contributor.author
Wang, Yangyang
dc.contributor.author
Piatkevich, Kiryl D.
dc.contributor.author
Boyden, Edward S.
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Mertz, Jerome
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Hasselmo, Michael E.
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Rotstein, Horacio
dc.contributor.author
Han, Xue
dc.date.available
2024-01-09T15:49:40Z
dc.date.issued
2023-08
dc.identifier.citation
Lowet, Eric; Sheehan, Daniel J.; Chialva, Ulises; De Oliveira Pena, Rodrigo; Mount, Rebecca A.; et al.; Theta and gamma rhythmic coding through two spike output modes in the hippocampus during spatial navigation; Cell Press; Cell Reports; 42; 8; 8-2023; 1-24
dc.identifier.uri
http://hdl.handle.net/11336/223080
dc.description.abstract
Hippocampal CA1 neurons generate single spikes and stereotyped bursts of spikes. However, it is unclear how individual neurons dynamically switch between these output modes and whether these two spiking outputs relay distinct information. We performed extracellular recordings in spatially navigating rats and cellular voltage imaging and optogenetics in awake mice. We found that spike bursts are preferentially linked to cellular and network theta rhythms (3–12 Hz) and encode an animal's position via theta phase precession, particularly as animals are entering a place field. In contrast, single spikes exhibit additional coupling to gamma rhythms (30–100 Hz), particularly as animals leave a place field. Biophysical modeling suggests that intracellular properties alone are sufficient to explain the observed input frequency-dependent spike coding. Thus, hippocampal neurons regulate the generation of bursts and single spikes according to frequency-specific network and intracellular dynamics, suggesting that these spiking modes perform distinct computations to support spatial behavior.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Cell Press
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
COMPLEX SPIKES
dc.subject
CP: NEUROSCIENCE
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NEURAL OSCILLATIONS
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OPTOGENETICS, BURSTS
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PLACE FIELDS
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PLATEAU POTENTIALS
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SOMARCHON
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SPATIAL NAVIGATION
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SUBTHRESHOLD VOLTAGE
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VOLTAGE IMAGING
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Otras Ciencias Biológicas
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Theta and gamma rhythmic coding through two spike output modes in the hippocampus during spatial navigation
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2024-01-09T10:08:30Z
dc.identifier.eissn
2211-1247
dc.journal.volume
42
dc.journal.number
8
dc.journal.pagination
1-24
dc.journal.pais
Estados Unidos
dc.description.fil
Fil: Lowet, Eric. Boston University; Estados Unidos
dc.description.fil
Fil: Sheehan, Daniel J.. Boston University; Estados Unidos
dc.description.fil
Fil: Chialva, Ulises. Universidad Nacional del Sur. Departamento de Matemática; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca; Argentina
dc.description.fil
Fil: De Oliveira Pena, Rodrigo. New Jersey Institute of Technology; Estados Unidos
dc.description.fil
Fil: Mount, Rebecca A.. Boston University; Estados Unidos
dc.description.fil
Fil: Xiao, Sheng. Boston University; Estados Unidos
dc.description.fil
Fil: Zhou, Samuel L.. Boston University; Estados Unidos
dc.description.fil
Fil: Tseng, Hua-an. Boston University; Estados Unidos
dc.description.fil
Fil: Gritton, Howard. University of Illinois. Urbana - Champaign; Estados Unidos
dc.description.fil
Fil: Shroff, Sanaya. Boston University; Estados Unidos
dc.description.fil
Fil: Kondabolu, Krishnakanth. Boston University; Estados Unidos
dc.description.fil
Fil: Cheung, Cyrus. Boston University; Estados Unidos
dc.description.fil
Fil: Wang, Yangyang. Boston University; Estados Unidos
dc.description.fil
Fil: Piatkevich, Kiryl D.. Westlake University; China
dc.description.fil
Fil: Boyden, Edward S.. McGovern Institute for Brain Research; Estados Unidos. Massachusetts Institute of Technology; Estados Unidos
dc.description.fil
Fil: Mertz, Jerome. Boston University; Estados Unidos
dc.description.fil
Fil: Hasselmo, Michael E.. Boston University; Estados Unidos
dc.description.fil
Fil: Rotstein, Horacio. New Jersey Institute of Technology; Estados Unidos
dc.description.fil
Fil: Han, Xue. Boston University; Estados Unidos
dc.journal.title
Cell Reports
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.celrep.2023.112906
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S2211124723009178
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