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dc.contributor.author
Hirota, Yasushi
dc.contributor.author
Burnum, Kristin E.
dc.contributor.author
Acar, Nuray
dc.contributor.author
Rabinovich, Gabriel Adrián
dc.contributor.author
Daikoku, Takiko
dc.contributor.author
Dey, Sudhansu K.
dc.date.available
2017-08-11T19:30:49Z
dc.date.issued
2012-05
dc.identifier.citation
Hirota, Yasushi; Burnum, Kristin E.; Acar, Nuray; Rabinovich, Gabriel Adrián; Daikoku, Takiko; et al.; Galectin-1 Markedly Reduces the Incidence of Resorptions in Mice Missing Immunophilin FKBP52; Oxford University Press; Endocrinology; 153; 5; 5-2012; 2486-2493
dc.identifier.issn
0013-7227
dc.identifier.uri
http://hdl.handle.net/11336/22248
dc.description.abstract
Progesterone (P4) signaling is critical for pregnancy.We previously showed that immunopilin FK506 binding protein (FKBP)52 serves as a cochaperone to optimize progesterone receptor (PR) function in the uterus, and its deficiency leads to P4 resistance in a pregnancy stage-specific and genetic background-dependent manner in mice. In particular, sc placement of SILASTIC implants carrying P4 rescued implantation failure in CD1 Fkbp52 / mice, but the resorption rate was substantially high at midgestation due to reduced P4 responsiveness. Because downstream targets of P4- FKBP52-PR signaling in the uterus to support pregnancy are not clearly understood, we performed proteomic analysis using Fkbp52 / , PR-deficient (Pgr / ), and wild-type (WT) uteri.We found that the expression of galectin-1 (Gal1), an evolutionarily conserved glycan-binding protein, was significantly down-regulated in both Fkbp52 / and Pgr / uteri compared with WT uteri. During early gestation, Lgals1, which encodes Gal1, was distinctly expressed in stromal and decidual cells. Lgals1 expression was much lower in d 4 Fkbp52 / uteri compared with WT uteri, and this reduction was reversed by P4 supplementation. More interestingly, concomitant supplementation of recombinant Gal1 significantly suppressed the high resorption rate and leukocyte infiltration at implantation sites in CD1 Fkbp52 / females carrying P4 SILASTIC implants. These findings suggest that uterine Gal1 is an important downstream target of P4-FKBP52-PR signaling in the uterus to support P4 responsiveness during pregnancy.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Oxford University Press
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Tacrolimus Binding Proteins
dc.subject
Pregnancy
dc.subject
Galectin-1
dc.subject
Immunophilins
dc.subject
Signal Traduction
dc.subject.classification
Bioquímica y Biología Molecular
dc.subject.classification
Medicina Básica
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Galectin-1 Markedly Reduces the Incidence of Resorptions in Mice Missing Immunophilin FKBP52
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-06-29T13:39:13Z
dc.identifier.eissn
1945-7170
dc.journal.volume
153
dc.journal.number
5
dc.journal.pagination
2486-2493
dc.journal.pais
Reino Unido
dc.journal.ciudad
Oxford
dc.description.fil
Fil: Hirota, Yasushi. University of Tokyo; Japón
dc.description.fil
Fil: Burnum, Kristin E.. Vanderbilt University; Estados Unidos
dc.description.fil
Fil: Acar, Nuray. Cincinnati Children's Hospital Medical Center; Estados Unidos
dc.description.fil
Fil: Rabinovich, Gabriel Adrián. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
dc.description.fil
Fil: Daikoku, Takiko. Cincinnati Children's Hospital Medical Center; Estados Unidos
dc.description.fil
Fil: Dey, Sudhansu K.. Cincinnati Children's Hospital Medical Center; Estados Unidos
dc.journal.title
Endocrinology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/endo/article-lookup/doi/10.1210/en.2012-1035
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1210/en.2012-1035
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3339653/
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