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dc.contributor.author
Gonzalez, Paula Natalia
dc.contributor.author
Kristensen, Erika
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Morck, Douglas W.
dc.contributor.author
Boyd, Steven
dc.contributor.author
Hallgrimsson; Benedikt
dc.date.available
2017-08-11T18:58:56Z
dc.date.issued
2013-03
dc.identifier.citation
Gonzalez, Paula Natalia; Kristensen, Erika; Morck, Douglas W.; Boyd, Steven; Hallgrimsson; Benedikt; Effects of growth hormone on the ontogenetic allometry of craniofacial bones; Wiley; Evolution and Development; 15; 2; 3-2013; 133-145
dc.identifier.issn
1525-142X
dc.identifier.uri
http://hdl.handle.net/11336/22232
dc.description.abstract
Organism size is controlled by interactions between genetic and environmental factors mediated by hormones with systemic and local effects. As changes in size are usually not isometric, a considerable diversity in shape can be generated through modifications in the patterns of ontogenetic allometry. In this study we evaluated the role of timing and dose of growth hormone (GH) release on growth and correlated shape changes in craniofacial bones. Using a longitudinal study design, we analyzed GH deficient mice treated with GH supplementation commencing pre- and post-puberty. We obtained 3D in vivo micro-CT images of the skull between 21 and 60 days of age and used geometric morphometrics to analyze size and shape changes among control and GH deficient treated and non-treated mice. The variable levels of circulating GH altered the size and shape of the adult skull, and influenced the cranial base, vault, and face differently. While cranial base synchondroses and facial sutures were susceptible to either the direct or indirect effect of GH supplementation, its effect was negligible on the vault. Such different responses support the role of intrinsic growth trajectories of skeletal components in controlling the modifications induced by systemic factors. Contrary to the expected, the timing of GH treatment did not have an effect on catch-up growth. GH levels also altered the ontogenetic trajectories by inducing changes in their location and extension in the shape space, indicating that differences arose before 21 days and were further accentuated by a truncation of the ontogenetic trajectories in GHD groups
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Wiley
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Lit/Lit Mice
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Geometric Morphometrics
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Modularity
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Growth Hormone
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Bioquímica y Biología Molecular
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Effects of growth hormone on the ontogenetic allometry of craniofacial bones
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-08-07T16:38:09Z
dc.journal.volume
15
dc.journal.number
2
dc.journal.pagination
133-145
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Hoboken
dc.description.fil
Fil: Gonzalez, Paula Natalia. University of Calgari; Canadá. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico CONICET- La Plata. Instituto de Genética Veterinaria "Ing. Fernando Noel Dulout". Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Instituto de Genética Veterinaria; Argentina. Alberta Children; Canadá. McCaig Institute for Bone and Joint Health; Canadá
dc.description.fil
Fil: Kristensen, Erika. McCaig Institute for Bone and Joint Health; Canadá. University of Calgary; Canadá
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Fil: Morck, Douglas W.. University of Calgary; Canadá
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Fil: Boyd, Steven. University of Calgary; Canadá
dc.description.fil
Fil: Hallgrimsson; Benedikt. University of Calgary; Canadá
dc.journal.title
Evolution and Development
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1111/ede.12025
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1111/ede.12025/abstract
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info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4120974/