Mostrar el registro sencillo del ítem
dc.contributor.author
Novosak, Marina Gisel
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.contributor.author
Winnik, Daniana Lilian
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.contributor.author
Laczeski, Margarita Ester
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.contributor.author
Quiroga, Marina Inés
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.date.available
2024-01-03T10:50:50Z
dc.date.issued
2022-12
dc.identifier.citation
Novosak, Marina Gisel; Winnik, Daniana Lilian; Laczeski, Margarita Ester; Quiroga, Marina Inés; Antibacterial activity of medicinal plants against Streptococcus agalactiae; SciCell s.r.o.; Nova Biotechnologica et Chimica; 21; 2; 12-2022; 1-11
dc.identifier.issn
1338-6905
dc.identifier.uri
http://hdl.handle.net/11336/222137
dc.description.abstract
Streptococcus agalactiae, group B Streptococcus (GBS), infects and causes severe diseases in humans and numerous animal species, including fish, given its ability to cross the host-specific barrier. The emergence of antibiotic resistant GBS strains makes it necessary to look for alternatives to treat and prevent infections that it produces. The aim of the present study was to determine the antibacterial activity of ethanolic and aqueous extracts of medicinal plants from Misiones province, northeast Argentina, against GBS from humans and fish. We used human Streptococcus agalactiae ATCC® BAA-611™ and tilapia Streptococcus agalactiae ATCC® 51487™ strains. Minimum Inhibitory Dose (MID) was determined by the disc diffusion method. Minimum Inhibitory Concentration (MIC), Minimum Bactericidal Concentration (MBC), MBC/MIC ratio, drug synergism with commercial antibiotics, and resistance assays were determined with extracts that showed antibacterial activity. Medium Lethal Dose 50 (LD50) was determined by the Artemia salina assay. For ethanolic and aqueous Eugenia uniflora L. extracts, we obtained a MID = 0.5 mg.disc-1. For both extracts of Eugenia uniflora L., the MIC and MBC values were 1 mg.mL-1 and 5 mg.mL-1, respectively. The MICI (MBC/MIC ratio) = 5 qualified the action of these extracts as bacteriostatic. The drug synergism assay with ampicillin, erythromycin, and clindamycin combination and extracts showed indifference. The LD50 of the aqueous extract was 0.82 mg.mL-1 indicating moderate toxicity. This work is a first step to identify chemical compounds in native medicinal plants of Misiones, Argentina, that could mean an alternative for the treatment of Streptococcus agalactiae infections.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
SciCell s.r.o.
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/
dc.subject
AQUEOUS EXTRACT
dc.subject
BACTERIAL
dc.subject
DRUG RESISTANCE
dc.subject
ETHANOLIC EXTRACT
dc.subject
MEDICINAL
dc.subject
PLANTS
dc.subject
STREPTOCOCCUS AGALACTIAE
dc.subject.classification
Bioquímica y Biología Molecular
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.subject.classification
Ciencias Biológicas
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.title
Antibacterial activity of medicinal plants against Streptococcus agalactiae
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2023-12-26T11:21:20Z
dc.identifier.eissn
1339-004X
dc.journal.volume
21
dc.journal.number
2
dc.journal.pagination
1-11
dc.journal.pais
Alemania
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.description.fil
Fil: Novosak, Marina Gisel. Universidad Nacional de Misiones; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste; Argentina
dc.description.fil
Fil: Winnik, Daniana Lilian. Universidad Nacional de Misiones; Argentina
dc.description.fil
Fil: Laczeski, Margarita Ester. Universidad Nacional de Misiones; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste; Argentina
dc.description.fil
Fil: Quiroga, Marina Inés. Universidad Nacional de Misiones; Argentina
dc.journal.title
Nova Biotechnologica et Chimica
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://journals.scicell.org/index.php/NBC/article/view/1264/801
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.36547/nbc.1264
Archivos asociados