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dc.contributor.author
Zold, Camila Lidia
dc.contributor.author
Escande, Mariela Veronica
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Pomata, Pablo Ernesto
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Riquelme, Luis A.
dc.contributor.author
Murer, Mario Gustavo
dc.date.available
2017-08-11T17:41:24Z
dc.date.issued
2012-03
dc.identifier.citation
Zold, Camila Lidia; Escande, Mariela Veronica; Pomata, Pablo Ernesto; Riquelme, Luis A.; Murer, Mario Gustavo; Striatal NMDA receptors gate cortico-pallidal synchronization in a rat model of Parkinson's disease; Elsevier Inc; Neurobiology of Disease; 47; 1; 3-2012; 38-48
dc.identifier.issn
0969-9961
dc.identifier.uri
http://hdl.handle.net/11336/22197
dc.description.abstract
Anomalous patterns of synchronization between basal ganglia and cortex underlie the symptoms of Parkinson´s disease. Computational modeling studies suggest that changes in cortical feedback loops involving trans-striatal and trans-subthalamic circuits bring up this anomalous synchronization. We asked whether striatal outflow synchronizes globus pallidus neurons with cortical activity in a rat model of Parkinson´s disease. We found that striatal firing is highly increased in rats with chronic nigrostriatal lesion and that this hyperactivity can be reduced by locally infusing a competitive NMDA receptor antagonist. Moreover, NMDA receptor-dependent striatal output had frequency dependent effects on distinct pathological patterns of cortico-pallidal coupling. Blockade of striatal NMDA receptors almost completely abolished an anomalous ~ 1 Hz cortico-pallidal anti-phase synchronization induced by nigrostriatal degeneration. Moreover, under striatal NMDA receptor blockade, synchronization with 2.5?5 Hz cortical oscillations falls to negligible levels and oscillations at 10?20 Hz are markedly attenuated, whereas beta synchronization (with a peak at ~ 26 Hz) is marginally reduced. Thus, tonic activation of striatal NMDA receptors allows different forms of anomalous oscillations along the cortico-striato-pallidal axis. Moreover, the frequency dependent effects of NMDA receptors suggest that low and high frequency parkinsonian oscillations stem from partially different mechanisms. Finally, our results may help to reconcile views about the contributions of changes in firing rate and oscillatory synchronization to Parkinson´s disease symptoms by showing that they are related to each other.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Inc
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
Striatum
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Nmda Receptor
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Globus Pallidus
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Neuronal Synchronization
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Parkinson´S Disease
dc.subject.classification
Bioquímica y Biología Molecular
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
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Neurociencias
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Striatal NMDA receptors gate cortico-pallidal synchronization in a rat model of Parkinson's disease
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-06-29T13:39:41Z
dc.identifier.eissn
1095-953X
dc.journal.volume
47
dc.journal.number
1
dc.journal.pagination
38-48
dc.journal.pais
Estados Unidos
dc.description.fil
Fil: Zold, Camila Lidia. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas. Laboratorio de Fisiología de Circuitos Neuronales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Escande, Mariela Veronica. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas. Laboratorio de Fisiología de Circuitos Neuronales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Pomata, Pablo Ernesto. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas. Laboratorio de Fisiología de Circuitos Neuronales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Riquelme, Luis A.. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas. Laboratorio de Fisiología de Circuitos Neuronales; Argentina
dc.description.fil
Fil: Murer, Mario Gustavo. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas. Laboratorio de Fisiología de Circuitos Neuronales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.journal.title
Neurobiology of Disease
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0969996112000939
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.nbd.2012.03.022
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