Abamectin and albendazole plasma profiles after their combined administration as a controlled release capsule in lambs

Abstract

In an attempt to overcome the inconvenient of the development of resistance to the available anthelmintic chemical groups, pharmaceutical formulations combining either two or three chemical entities have been developed. Several preparations combining benzimidazole and macrocyclic lactone compounds are available in the veterinary pharmaceutical market, including an intra-ruminal controlled release capsule for use in sheep. The goal of the current work was to investigate the disposition kinetics of both abamectin (ABA) and albendazole (ABZ) after their oral administration as a combined controlled-release capsule in lambs.