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Artículo

Novel antibacterial bioactive glass nanocomposite functionalized with tetracycline hydrochloride

Rivadeneira, JosefinaIcon ; Luz, Gisela M.; Audisio, Marcela CarinaIcon ; Mano, Joao F.; Gorustovich Alonso, Alejandro AdrianIcon
Fecha de publicación: 10/2015
Editorial: De Gruyter
Revista: Biomedical Glasses
e-ISSN: 2299-3932
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Bioquímica y Biología Molecular

Resumen

To prevent the high frequency of wound infections, anti-bacterial agents can be loaded onto composites. In the present study, the antibiotic tetracycline hydrochloride (TC)was incorporated, for the first time, in collagen type I membranes coated with nano-sized SiO2-CaOP2O5 bioactive glass (n-BG) obtained by a sol-gel chemical route. Collagen membranes coated with n-BG were immersed in simulated body fluid (SBF) containing 0.25, 0.75 or 1.25 mg mL−1 of TC for 48 h at 37∘C following a coprecipitation method. The antibiotic was released in distilledwater at 37∘C for up to 72 h. The antibacterial activity of the composites was evaluated in vitro by the inhibition zone test and plate count method. Two different Staphylococcus aureus strains, S. aureus ATCC29213 and S. aureus ATCC25923, were exposed to the biomaterials. The results showed that the incorporation but not the release of TC was dependent on the initial concentration of TC in SBF. The biomaterials inhibited S. aureus growth, although the efficacy was similar for all the concentrations. The results allow us to conclude that the new composite could have potential in the prevention of wound infections.
Palabras clave: Bioactive Glasses , Antibacterial Activity , Nanocomposite
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/22135
DOI: http://dx.doi.org/10.1515/bglass-2015-0012
URL: https://www.degruyter.com/view/j/bglass.2015.1.issue-1/bglass-2015-0012/bglass-2
Colecciones
Articulos(INTECIN) [362]
Articulos de INST.D/TEC.Y CS.DE LA ING."HILARIO FERNANDEZ LONG"
Articulos(INIQUI) [435]
Articulos de INST.DE INVEST.PARA LA INDUSTRIA QUIMICA (I)
Citación
Rivadeneira, Josefina; Luz, Gisela M.; Audisio, Marcela Carina; Mano, Joao F.; Gorustovich Alonso, Alejandro Adrian; Novel antibacterial bioactive glass nanocomposite functionalized with tetracycline hydrochloride; De Gruyter; Biomedical Glasses; 1; 1; 10-2015; 128-135
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