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dc.contributor.author
Recouvreux, Maria Victoria
dc.contributor.author
Lapyckyj, Lara
dc.contributor.author
Camilletti, María Andrea
dc.contributor.author
Guida, María Clara
dc.contributor.author
Ornstein, Ana Maria
dc.contributor.author
Rifkin, Daniel B.
dc.contributor.author
Becu, Damasia
dc.contributor.author
Diaz, Graciela Susana
dc.date.available
2015-09-30T16:00:22Z
dc.date.issued
2013-09-05
dc.identifier.citation
Recouvreux, Maria Victoria; Lapyckyj, Lara; Camilletti, María Andrea; Guida, María Clara; Ornstein, Ana Maria; et al.; Sex differences in the pituitary transforming growth factor-beta1 (TGF-beta1) system: studies in a model of resistant prolactinomas; Endocrine Soc; Endocrinology; 154; 11; 5-9-2013; 4192-4205
dc.identifier.issn
0013-7227
dc.identifier.issn
http://dx.doi.org/10.1210/en.2013-1433
dc.identifier.uri
http://hdl.handle.net/11336/2212
dc.description.abstract
Dopamine and estradiol interact in the regulation of lactotroph cell proliferation and prolactin secretion. Ablation of the dopamine D2 receptor gene (Drd2 / ) in mice leads to a sexually dimorphic phenotype of hyperprolactinemia and pituitary hyperplasia, which is stronger in females. TGF- 1 is a known inhibitor of lactotroph proliferation. TGF- 1 is regulated by dopamine and estradiol, and it is usually down-regulated in prolactinoma experimental models. To understand the role of TGF- 1 in the gender-specific development of prolactinomas in Drd2 / mice, we compared the expression of different components of the pituitary TGF- 1 system, including active cytokine content, latent TGF- –binding protein isoforms, and possible local TGF- 1 activators, in males and females in this model. Furthermore, we evaluated the effects of dopamine and estradiol administration to elucidate their role in TGF- 1 system regulation. The expression of active TGF- 1, latent TGF- –binding protein isoforms, and several putative TGF- 1 activators evaluated was higher in male than in female mouse pituitary glands. However, Drd2 / female mice were more sensitive to the decrease in active TGF- 1 content, as reflected by the down-regulation of TGF- 1 target genes. Estrogen and dopamine caused differential regulation of several components of the TGF- 1 system. In particular, we found sex- and genotype- dependent regulation of active TGF- 1 content and a similar expression pattern for 2 of the putative TGF- 1 activators, thrombospondin-1 and kallikrein-1, suggesting that these proteins could mediate TGF- 1 activation elicited by dopamine and estradiol. Our results indicate that (1) the loss of dopaminergic tone affects the pituitary TGF- 1 system more strongly in females than in males, (2) males express higher levels of pituitary TGF- 1 system components including active cytokine, and (3) estradiol negatively controls most of the components of the system. Because TGF- 1 inhibits lactotroph proliferation, we propose that the higher levels of the TGF- 1 system in males could protect or delay the development of prolactinomas in Drd2 / male mice.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Endocrine Soc
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
Prolactin
dc.subject
Tgf Beta
dc.subject
Pituitary
dc.subject
Sex Differences
dc.subject.classification
Fisiología
dc.subject.classification
Medicina Básica
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.subject.classification
Otras Medicina Básica
dc.subject.classification
Medicina Básica
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Sex differences in the pituitary transforming growth factor-beta1 (TGF-beta1) system: studies in a model of resistant prolactinomas
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-03-30 10:35:44.97925-03
dc.identifier.eissn
1945-7170
dc.journal.volume
154
dc.journal.number
11
dc.journal.pagination
4192-4205
dc.journal.pais
Estados Unidos de América
dc.journal.ciudad
California
dc.description.fil
Fil: Recouvreux, Maria Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina;
dc.description.fil
Fil: Lapyckyj, Lara. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina;
dc.description.fil
Fil: Camilletti, María Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina;
dc.description.fil
Fil: Guida, María Clara. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina;
dc.description.fil
Fil: Ornstein, Ana Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina;
dc.description.fil
Fil: Rifkin, Daniel B.. New York University Medical Center. Department of Cell Biology; Estados Unidos de América;
dc.description.fil
Fil: Becu, Damasia. Consejo Nacional de Investigaciones Científicas y Técnicas -conicet. Instituto de Biología y Medicina Experimental (i); Argentina;
dc.description.fil
Fil: Diaz, Graciela Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina;
dc.journal.title
Endocrinology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3800752/
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://press.endocrine.org/doi/pdf/10.1210/en.2013-1433


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