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dc.contributor.author
Laseca, Nora
dc.contributor.author
Cánovas, Ángela
dc.contributor.author
Valera, Mercedes
dc.contributor.author
Id Lahoucine, Samir
dc.contributor.author
Perdomo González, Davinia Isabel
dc.contributor.author
Fonseca, Pablo A. S.
dc.contributor.author
Demyda-peyrás, Sebastian
dc.contributor.author
Molina, Antonio
dc.date.available
2023-12-21T13:59:23Z
dc.date.issued
2023-08
dc.identifier.citation
Laseca, Nora; Cánovas, Ángela; Valera, Mercedes; Id Lahoucine, Samir; Perdomo González, Davinia Isabel; et al.; Genomic screening of allelic and genotypic transmission ratio distortion in horse; Public Library of Science; Plos One; 18; 8-2023; 1-16
dc.identifier.issn
1932-6203
dc.identifier.uri
http://hdl.handle.net/11336/221105
dc.description.abstract
The phenomenon in which the expected Mendelian inheritance is altered is known as transmission ratio distortion (TRD). The TRD analysis relies on the study of the transmission of one of the two alleles from a heterozygous parent to the offspring. These distortions are due to biological mechanisms affecting gametogenesis, embryo development and/or postnatal viability, among others. In this study, TRD phenomenon was characterized in horses using SNP-by-SNP model by TRDscan v.2.0 software. A total of 1,041 Pura Raza Español breed horses were genotyped with 554,634 SNPs. Among them, 277 horses genotyped in trios (stallion-mare-offspring) were used to perform the TRD analysis. Our results revealed 140 and 42 SNPs with allelic and genotypic patterns, respectively. Among them, 63 displayed stallion-TRD and 41 exhibited mare-TRD, while 36 SNPs showed overall TRD. In addition, 42 SNPs exhibited heterosis pattern. Functional analyses revealed that the annotated genes located within the TRD regions identified were associated with biological processes and molecular functions related to spermatogenesis, oocyte division, embryonic development, and hormonal activity. A total of 10 functional candidate genes related to fertility were found. To our knowledge, this is the most extensive study performed to evaluate the presence of alleles and functional candidate genes with transmission ratio distortion affecting reproductive performance in the domestic horse.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Public Library of Science
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
horse
dc.subject
genomics
dc.subject
TRD
dc.subject.classification
Tecnología GM, clonación de ganado, selección asistida, diagnósticos, tecnología de producción de biomasa, etc.
dc.subject.classification
Biotecnología Agropecuaria
dc.subject.classification
CIENCIAS AGRÍCOLAS
dc.title
Genomic screening of allelic and genotypic transmission ratio distortion in horse
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2023-12-21T11:04:59Z
dc.journal.volume
18
dc.journal.pagination
1-16
dc.journal.pais
Estados Unidos
dc.description.fil
Fil: Laseca, Nora. Universidad de Córdoba; España
dc.description.fil
Fil: Cánovas, Ángela. University of Guelph; Canadá
dc.description.fil
Fil: Valera, Mercedes. Universidad de Sevilla; España
dc.description.fil
Fil: Id Lahoucine, Samir. Scotland’s Rural College; Reino Unido
dc.description.fil
Fil: Perdomo González, Davinia Isabel. Universidad de Sevilla; España
dc.description.fil
Fil: Fonseca, Pablo A. S.. Universidad de León; España
dc.description.fil
Fil: Demyda-peyrás, Sebastian. Universidad de Córdoba; España. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Molina, Antonio. Universidad de Córdoba; España
dc.journal.title
Plos One
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1371/journal.pone.0289066
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