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dc.contributor.author
Aspromonte, Maria Cristina
dc.contributor.author
Nugnes, María Victoria
dc.contributor.author
Quaglia, Federica
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Bouharoua, Adel
dc.contributor.author
Sagris, Vasileios
dc.contributor.author
Promponas, Vasilis J.
dc.contributor.author
Chasapi, Anastasia
dc.contributor.author
Fichó, Erzsébet
dc.contributor.author
Balatti, Galo Ezequiel
dc.contributor.author
Parisi, Gustavo Daniel
dc.contributor.author
González Buitrón, Martín
dc.contributor.author
Erdos, Gabor
dc.contributor.author
Pajkos, Matyas
dc.contributor.author
Dosztányi, Zsuzsanna
dc.contributor.author
Dobson, Laszlo
dc.contributor.author
Conte, Alessio Del
dc.contributor.author
Clementel, Damiano
dc.contributor.author
Salladini, Edoardo
dc.contributor.author
DisProt Consortium
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Ku, Luiggi G Tenorio
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Monzon, Alexander Miguel
dc.contributor.author
Tompa, Peter
dc.contributor.author
Lazar, Tamas
dc.contributor.author
Tosatto, Silvio C E
dc.contributor.author
Piovesan, Damiano
dc.date.available
2023-12-20T15:37:29Z
dc.date.issued
2023-10
dc.identifier.citation
Aspromonte, Maria Cristina; Nugnes, María Victoria; Quaglia, Federica; Bouharoua, Adel; Sagris, Vasileios; et al.; DisProt in 2024: improving function annotation of intrinsically disordered proteins; Oxford University Press; Nucleic Acids Research; 2023; 10-2023; 1-8
dc.identifier.issn
0305-1048
dc.identifier.uri
http://hdl.handle.net/11336/220952
dc.description.abstract
DisProt (URL: https://disprot.org) is the gold standard database for intrinsically disordered proteins and regions, providing valuable information about their functions. The latest version of DisProt brings significant advancements, including a broader representation of functions and an enhanced curation process. These improvements aim to increase both the quality of annotations and their coverage at the sequence level. Higher coverage has been achieved by adopting additional evidence codes. Quality of annotations has been improved by systematically applying Minimum Information About Disorder Experiments (MIADE) principles and reporting all the details of the experimental setup that could potentially influence the structural state of a protein. The DisProt database now includes new thematic datasets and has expanded the adoption of Gene Ontology terms, resulting in an extensive functional repertoire which is automatically propagated to UniProtKB. Finally, we show that DisProt's curated annotations strongly correlate with disorder predictions inferred from AlphaFold2 pLDDT (predicted Local Distance Difference Test) confidence scores. This comparison highlights the utility of DisProt in explaining apparent uncertainty of certain well-defined predicted structures, which often correspond to folding-upon-binding fragments. Overall, DisProt serves as a comprehensive resource, combining experimental evidence of disorder information to enhance our understanding of intrinsically disordered proteins and their functional implications.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Oxford University Press
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
IDPS
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IDRS
dc.subject
DATABASES
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Ciencias de la Información y Bioinformática
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Ciencias de la Computación e Información
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CIENCIAS NATURALES Y EXACTAS
dc.title
DisProt in 2024: improving function annotation of intrinsically disordered proteins
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2023-12-11T16:13:57Z
dc.identifier.eissn
1362-4962
dc.journal.volume
2023
dc.journal.pagination
1-8
dc.journal.pais
Reino Unido
dc.journal.ciudad
Oxford
dc.description.fil
Fil: Aspromonte, Maria Cristina. Università di Padova; Italia
dc.description.fil
Fil: Nugnes, María Victoria. Università di Padova; Italia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Quaglia, Federica. Università di Padova; Italia
dc.description.fil
Fil: Bouharoua, Adel. Università di Padova; Italia
dc.description.fil
Fil: Sagris, Vasileios. UNIVERSITY OF CYPRUS (UC);
dc.description.fil
Fil: Promponas, Vasilis J.. UNIVERSITY OF CYPRUS (UC);
dc.description.fil
Fil: Chasapi, Anastasia. Centre For Research And Technology - Hellas ; Chemical Process & Energy Resources Institute;
dc.description.fil
Fil: Fichó, Erzsébet. Cytocast Hungary; Hungría
dc.description.fil
Fil: Balatti, Galo Ezequiel. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Parisi, Gustavo Daniel. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: González Buitrón, Martín. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Erdos, Gabor. Eötvös University; Argentina
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Fil: Pajkos, Matyas. Eotvos University, Budapest. Department Of Materials Physics; Argentina
dc.description.fil
Fil: Dosztányi, Zsuzsanna. Eotvos University, Budapest. Department Of Materials Physics; Argentina
dc.description.fil
Fil: Dobson, Laszlo. Semmelweis University; Hungría
dc.description.fil
Fil: Conte, Alessio Del. Università di Padova; Italia
dc.description.fil
Fil: Clementel, Damiano. Università di Padova; Italia
dc.description.fil
Fil: Salladini, Edoardo. Università di Padova; Italia
dc.description.fil
Fil: DisProt Consortium. Università di Padova; Italia
dc.description.fil
Fil: Ku, Luiggi G Tenorio. Università di Padova; Italia
dc.description.fil
Fil: Monzon, Alexander Miguel. Università di Padova; Italia
dc.description.fil
Fil: Tompa, Peter. Vrije Unviversiteit Brussel; Bélgica
dc.description.fil
Fil: Lazar, Tamas. Vrije Unviversiteit Brussel; Bélgica
dc.description.fil
Fil: Tosatto, Silvio C E. Università di Padova; Italia
dc.description.fil
Fil: Piovesan, Damiano. Università di Padova; Italia
dc.journal.title
Nucleic Acids Research
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkad928/7334088
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1093/nar/gkad928
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