Mostrar el registro sencillo del ítem

dc.contributor.author
Aspromonte, Maria Cristina  
dc.contributor.author
Nugnes, María Victoria  
dc.contributor.author
Quaglia, Federica  
dc.contributor.author
Bouharoua, Adel  
dc.contributor.author
Sagris, Vasileios  
dc.contributor.author
Promponas, Vasilis J.  
dc.contributor.author
Chasapi, Anastasia  
dc.contributor.author
Fichó, Erzsébet  
dc.contributor.author
Balatti, Galo Ezequiel  
dc.contributor.author
Parisi, Gustavo Daniel  
dc.contributor.author
González Buitrón, Martín  
dc.contributor.author
Erdos, Gabor  
dc.contributor.author
Pajkos, Matyas  
dc.contributor.author
Dosztányi, Zsuzsanna  
dc.contributor.author
Dobson, Laszlo  
dc.contributor.author
Conte, Alessio Del  
dc.contributor.author
Clementel, Damiano  
dc.contributor.author
Salladini, Edoardo  
dc.contributor.author
DisProt Consortium  
dc.contributor.author
Ku, Luiggi G Tenorio  
dc.contributor.author
Monzon, Alexander Miguel  
dc.contributor.author
Tompa, Peter  
dc.contributor.author
Lazar, Tamas  
dc.contributor.author
Tosatto, Silvio C E  
dc.contributor.author
Piovesan, Damiano  
dc.date.available
2023-12-20T15:37:29Z  
dc.date.issued
2023-10  
dc.identifier.citation
Aspromonte, Maria Cristina; Nugnes, María Victoria; Quaglia, Federica; Bouharoua, Adel; Sagris, Vasileios; et al.; DisProt in 2024: improving function annotation of intrinsically disordered proteins; Oxford University Press; Nucleic Acids Research; 2023; 10-2023; 1-8  
dc.identifier.issn
0305-1048  
dc.identifier.uri
http://hdl.handle.net/11336/220952  
dc.description.abstract
DisProt (URL: https://disprot.org) is the gold standard database for intrinsically disordered proteins and regions, providing valuable information about their functions. The latest version of DisProt brings significant advancements, including a broader representation of functions and an enhanced curation process. These improvements aim to increase both the quality of annotations and their coverage at the sequence level. Higher coverage has been achieved by adopting additional evidence codes. Quality of annotations has been improved by systematically applying Minimum Information About Disorder Experiments (MIADE) principles and reporting all the details of the experimental setup that could potentially influence the structural state of a protein. The DisProt database now includes new thematic datasets and has expanded the adoption of Gene Ontology terms, resulting in an extensive functional repertoire which is automatically propagated to UniProtKB. Finally, we show that DisProt's curated annotations strongly correlate with disorder predictions inferred from AlphaFold2 pLDDT (predicted Local Distance Difference Test) confidence scores. This comparison highlights the utility of DisProt in explaining apparent uncertainty of certain well-defined predicted structures, which often correspond to folding-upon-binding fragments. Overall, DisProt serves as a comprehensive resource, combining experimental evidence of disorder information to enhance our understanding of intrinsically disordered proteins and their functional implications.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Oxford University Press  
dc.rights
info:eu-repo/semantics/restrictedAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
IDPS  
dc.subject
IDRS  
dc.subject
DATABASES  
dc.subject.classification
Ciencias de la Información y Bioinformática  
dc.subject.classification
Ciencias de la Computación e Información  
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS  
dc.title
DisProt in 2024: improving function annotation of intrinsically disordered proteins  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2023-12-11T16:13:57Z  
dc.identifier.eissn
1362-4962  
dc.journal.volume
2023  
dc.journal.pagination
1-8  
dc.journal.pais
Reino Unido  
dc.journal.ciudad
Oxford  
dc.description.fil
Fil: Aspromonte, Maria Cristina. Università di Padova; Italia  
dc.description.fil
Fil: Nugnes, María Victoria. Università di Padova; Italia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina  
dc.description.fil
Fil: Quaglia, Federica. Università di Padova; Italia  
dc.description.fil
Fil: Bouharoua, Adel. Università di Padova; Italia  
dc.description.fil
Fil: Sagris, Vasileios. UNIVERSITY OF CYPRUS (UC);  
dc.description.fil
Fil: Promponas, Vasilis J.. UNIVERSITY OF CYPRUS (UC);  
dc.description.fil
Fil: Chasapi, Anastasia. Centre For Research And Technology - Hellas ; Chemical Process & Energy Resources Institute;  
dc.description.fil
Fil: Fichó, Erzsébet. Cytocast Hungary; Hungría  
dc.description.fil
Fil: Balatti, Galo Ezequiel. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina  
dc.description.fil
Fil: Parisi, Gustavo Daniel. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina  
dc.description.fil
Fil: González Buitrón, Martín. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina  
dc.description.fil
Fil: Erdos, Gabor. Eötvös University; Argentina  
dc.description.fil
Fil: Pajkos, Matyas. Eotvos University, Budapest. Department Of Materials Physics; Argentina  
dc.description.fil
Fil: Dosztányi, Zsuzsanna. Eotvos University, Budapest. Department Of Materials Physics; Argentina  
dc.description.fil
Fil: Dobson, Laszlo. Semmelweis University; Hungría  
dc.description.fil
Fil: Conte, Alessio Del. Università di Padova; Italia  
dc.description.fil
Fil: Clementel, Damiano. Università di Padova; Italia  
dc.description.fil
Fil: Salladini, Edoardo. Università di Padova; Italia  
dc.description.fil
Fil: DisProt Consortium. Università di Padova; Italia  
dc.description.fil
Fil: Ku, Luiggi G Tenorio. Università di Padova; Italia  
dc.description.fil
Fil: Monzon, Alexander Miguel. Università di Padova; Italia  
dc.description.fil
Fil: Tompa, Peter. Vrije Unviversiteit Brussel; Bélgica  
dc.description.fil
Fil: Lazar, Tamas. Vrije Unviversiteit Brussel; Bélgica  
dc.description.fil
Fil: Tosatto, Silvio C E. Università di Padova; Italia  
dc.description.fil
Fil: Piovesan, Damiano. Università di Padova; Italia  
dc.journal.title
Nucleic Acids Research  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkad928/7334088  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1093/nar/gkad928