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dc.contributor.author
Arntz, Jeanne L.
dc.contributor.author
Alhasan, Moumen M
dc.contributor.author
Datye, Swarali
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Kahhaleh, Fariz G
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Almousa, Yahia
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Barrientos, Gabriela Laura
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Schwiertz, Andreas
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Conrad, Melanie L.
dc.date.available
2023-12-15T18:39:57Z
dc.date.issued
2023-10
dc.identifier.citation
Arntz, Jeanne L.; Alhasan, Moumen M; Datye, Swarali; Kahhaleh, Fariz G; Almousa, Yahia; et al.; Low-dose perinatal supplementation with Enterococcus faecalis increases concentrations of short-chain fatty acids in the offspring but does not protect against allergic asthma; Oxford University Press; International Immunology; 35; 10; 10-2023; 475-482
dc.identifier.issn
0953-8178
dc.identifier.uri
http://hdl.handle.net/11336/220530
dc.description.abstract
Childhood allergic asthma is associated with a dysbiotic gut microbiome in early life, and maternal perinatal treatment with probiotics is a potential way alter the infant microbiome, which may improve asthma outcomes. This study used a mouse model to examine the effect of maternal supplementation with the probiotic Enterococcus faecalis on faecal short-chain fatty acid (SCFA) concentrations and asthma risk in the offspring. Pregnant/lactating mice were treated daily, from gestation day 6 to postnatal day 21, with an oral suspension of 106, 107 or 108 colony-forming units of a live preparation of the probiotic E. faecalis (Symbioflor®1). At weaning, offspring were subjected to an ovalbumin-induced experimental asthma protocol. Faeces were collected from the mothers and offspring at several different time points to determine SCFA concentrations. It was found that maternal supplementation with E. faecalis did not alter litter size, sex ratio or offspring weight, and was associated with an increase in SCFAs in offspring faeces at weaning and after allergy induction. However, allergic offspring from E. faecalis supplemented mothers showed no difference in asthma severity when compared with allergic offspring from control mothers. In conclusion, although maternal perinatal supplementation with low-dose E. faecalis was associated with increased faecal SCFAs in the offspring, it did not protect against offspring asthma. This is may be because SCFA concentrations were not increased to an immunoprotective level. We recommend that future studies concentrate on probiotic supplementation in high-risk cases, for instance, to repair gut dysbiosis resulting from antibiotic use in pregnant mothers or their infants.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Oxford University Press
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
ASTHMA
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DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE
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MOUSE MODEL
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PREGNANCY
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PROBIOTIC
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Inmunología
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Low-dose perinatal supplementation with Enterococcus faecalis increases concentrations of short-chain fatty acids in the offspring but does not protect against allergic asthma
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2023-12-15T14:00:38Z
dc.journal.volume
35
dc.journal.number
10
dc.journal.pagination
475-482
dc.journal.pais
Reino Unido
dc.journal.ciudad
Oxford
dc.description.fil
Fil: Arntz, Jeanne L.. Berliner Institut Für Gesundheitsforschung; Alemania
dc.description.fil
Fil: Alhasan, Moumen M. Berliner Institut Für Gesundheitsforschung; Alemania
dc.description.fil
Fil: Datye, Swarali. Berliner Institut Für Gesundheitsforschung; Alemania
dc.description.fil
Fil: Kahhaleh, Fariz G. Berliner Institut Für Gesundheitsforschung; Alemania
dc.description.fil
Fil: Almousa, Yahia. Berliner Institut Für Gesundheitsforschung; Alemania
dc.description.fil
Fil: Barrientos, Gabriela Laura. Hospital Alemán. Laboratorio de Medicina Experimental; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
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Fil: Schwiertz, Andreas. MVZ Institute of Microecology GmbH; Alemania
dc.description.fil
Fil: Conrad, Melanie L.. Berliner Institut Für Gesundheitsforschung; Alemania
dc.journal.title
International Immunology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1093/intimm/dxad025
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/intimm/article/35/10/475/7226237
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