Artículo
Iodothyronine–phospholipid interactions in the lipid gel phase probed by Raman spectral markers
Fecha de publicación:
05/2013
Editorial:
Elsevier
Revista:
Spectrochimica Acta A: Molecular And Biomolecular Spectroscopy
ISSN:
0584-8539
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
A better understanding of the structural effects induced by thyroid hormones in model membranes is attained by Raman spectroscopy. The interactions of T3 and T4 with multilamellar vesicles of dipalmytoylphosphatidylcholine (DPPC) in the gel phase are characterized by analyzing the spectral behavior of the C–H and C–C stretching vibrations of the acyl chains. The spectra evidence an increase in the relative number of gauche conformation, which indicates the hormones are able to penetrate into the hydrophobic region of the bilayer and partially alter the lipid structure. In addition, the density packing of the acyl chains appears increased and the rotational mobility of the terminal methylene groups is slightly reduced in the iodothyronine/DPPC mixtures. These effects are interpreted in terms of the transition to an interdigitated phase due to the hormone incorporation to the membrane. The polar heads of the lipids also interact with the hormone, as evidenced by the PO 2 symmetric stretching band.
Palabras clave:
Dppc Liposomes
,
Lipid Gel Phase
,
Raman Spectroscopy
,
Thyroid Hormones
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Identificadores
Colecciones
Articulos(INQUINOA)
Articulos de INST.DE QUIMICA DEL NOROESTE
Articulos de INST.DE QUIMICA DEL NOROESTE
Articulos(INSIBIO)
Articulos de INST.SUP.DE INVEST.BIOLOGICAS
Articulos de INST.SUP.DE INVEST.BIOLOGICAS
Citación
Petruk, Ariel Alcides; Sosa Morales, Marcelo Clemente; Alvarez, Rosa Maria Susana; Iodothyronine–phospholipid interactions in the lipid gel phase probed by Raman spectral markers; Elsevier; Spectrochimica Acta A: Molecular And Biomolecular Spectroscopy; 112; 5-2013; 403-409
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