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dc.contributor.author
Fonseca Peña, Shirley Vivian Daniela  
dc.contributor.author
Brodeur, Celine Marie Julie  
dc.date.available
2023-12-12T12:06:02Z  
dc.date.issued
2023-06  
dc.identifier.citation
Fonseca Peña, Shirley Vivian Daniela; Brodeur, Celine Marie Julie; Toxicity and effects on anuran tadpole metamorphosis of the anthranilic diamide insecticides chlorantraniliprole and cyantraniliprole; Taylor & Francis; Journal of Toxicology and Environmental Health-Part A-Current Issues; 86; 15; 6-2023; 518-533  
dc.identifier.issn
1528-7394  
dc.identifier.uri
http://hdl.handle.net/11336/219919  
dc.description.abstract
The present study examined the acute and chronic toxicity attributed to commercial formulations of the anthranilic diamide insecticides chlorantraniliprole (CHLO) and cyantraniliprole (CYAN) on the neotropical amphibian species Rhinella arenarum, Rhinella fernandezae and Scinax granulatus. The median lethal concentrations obtained after 96 hr exposure (96 hr-LC50) were generally greater than 100 mg/L, except for stage 25 S. Granulatus, which were the most sensitive animals tested with a 96 hr-LC50 value of 46.78 mg/L. In subchronic exposures of R. arenarum, the 21day-LC50 were 151.4 mg/L for CHLO and >160 mg/L for CYAN, the weight gain of the tadpoles during this period not being markedly affected in both cases. Finally, when tadpoles of R. arenarum were exposed to CHLO throughout the metamorphic process, an inverted U-shaped non-monotonic dose-response relationship was observed between exposure concentrations and both % of individuals transiting between stage 39 and 42 and the time required to accomplish this. Data obtained raise the hypothesis of an effect of CHLO on the hypothalamic-pituitary-thyroid (HPT) axis, either directly or through an interaction with the stress-hormone system, as metamorphic progression from stage 39 to S42 occurs under the strict control of thyroid hormones. These observations are important as the anthranilic diamide insecticides are not currently known as endocrine disruptors. Further investigations are needed to clarify the pathways leading to these effects and examine whether environmentally-relevant aquatic concentrations of anthranilic diamides might be impacting amphibian populations in the wild.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Taylor & Francis  
dc.rights
info:eu-repo/semantics/restrictedAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
ANTHRANILIC DIAMIDES  
dc.subject
FROG  
dc.subject
METAMORPHOSIS  
dc.subject
PESTICIDE  
dc.subject
TOAD  
dc.subject.classification
Otras Ciencias Biológicas  
dc.subject.classification
Ciencias Biológicas  
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS  
dc.title
Toxicity and effects on anuran tadpole metamorphosis of the anthranilic diamide insecticides chlorantraniliprole and cyantraniliprole  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2023-12-11T17:57:58Z  
dc.journal.volume
86  
dc.journal.number
15  
dc.journal.pagination
518-533  
dc.journal.pais
Estados Unidos  
dc.description.fil
Fil: Fonseca Peña, Shirley Vivian Daniela. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación de Recursos Naturales; Argentina  
dc.description.fil
Fil: Brodeur, Celine Marie Julie. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación de Recursos Naturales; Argentina  
dc.journal.title
Journal of Toxicology and Environmental Health-Part A-Current Issues  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1080/15287394.2023.2224366