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dc.contributor.author
Yerien, Damián Emilio
dc.contributor.author
Barata Vallejo, Sebastian
dc.contributor.author
Postigo, Jose Alberto
dc.date.available
2023-12-06T14:25:38Z
dc.date.issued
2023-05
dc.identifier.citation
Yerien, Damián Emilio; Barata Vallejo, Sebastian; Postigo, Jose Alberto; Radical Perfluoroalkylation of Aliphatic Substrates; American Chemical Society; ACS Catalysis; 13; 12; 5-2023; 7756-7794
dc.identifier.issn
2155-5435
dc.identifier.uri
http://hdl.handle.net/11336/219484
dc.description.abstract
A selection of perfluoroalkylation reactions of aliphatic substrates that display methodological and synthetic amplitude will be studied, giving examples of their applications and mechanistic details. An array of synthetic approaches for fluoroalkylation reactions are documented; in particular, radical protocols are prominent among perfluoroalkylation methods. To that effect, addition reactions of perfluoroalkyl radicals RF (RF=CnF2n+1, n > 1) to unsaturated organic substrates serve as one of the most direct and efficacious ways to access fluoroalkylated scaffolds. The syntheses of perfluoroalkyl-substituted vinyl, alkynyl, and allylic compounds; the syntheses of perfluoroalkyl-substituted hydro-, iodo-, and oxy-perfluoroalkylated alkanes and olefins; the syntheses of perfluoroalkyl-substituted carbonyl compounds; the syntheses of perfluoroalkyl-substituted enamides, amides, thioamides, and hydrazones; and multicomponent perfluoroalkylation reactions will be studied. While there are a number of accomplished reports on organofluorination, we aim to provide an overview of radical-involved perfluoroalkylation reactions of aliphatic substrates, covering examples from 2018 to early 2023, as summarized in Tables 1-4.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
American Chemical Society
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
PERFLUOROALKYLATED ALIPHATIC SUBSTRATES
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PERFLUOROALKYLATED AMIDES
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PERFLUOROALKYLATED ENAMINES
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PERFLUOROALKYLATED THIOAMIDES
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PERFLUOROALKYLATED VINYL COMPOUNDS
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PERFLUOROALKYLATION
dc.subject.classification
Química Orgánica
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Ciencias Químicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Radical Perfluoroalkylation of Aliphatic Substrates
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2023-12-05T15:05:09Z
dc.journal.volume
13
dc.journal.number
12
dc.journal.pagination
7756-7794
dc.journal.pais
Estados Unidos
dc.description.fil
Fil: Yerien, Damián Emilio. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Orgánica. Cátedra de Química Orgánica I; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Barata Vallejo, Sebastian. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Orgánica. Cátedra de Química Orgánica I; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Postigo, Jose Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Orgánica. Cátedra de Química Orgánica I; Argentina
dc.journal.title
ACS Catalysis
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://pubs.acs.org/doi/10.1021/acscatal.3c01922
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1021/acscatal.3c01922
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