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dc.contributor.author
Giménez, Mabel Dionisia
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dc.contributor.author
Hughes, Jonathan J.
dc.contributor.author
Scascitelli, Moira
dc.contributor.author
Gabriel, Sofia I.
dc.contributor.author
Förster, Daniel W.
dc.contributor.author
Panithanarak, Thadsin
dc.contributor.author
Hauffe, Heidi C.
dc.contributor.author
Searle, Jeremy Byron
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dc.date.available
2023-12-06T12:15:38Z
dc.date.issued
2022-12
dc.identifier.citation
Giménez, Mabel Dionisia; Hughes, Jonathan J.; Scascitelli, Moira; Gabriel, Sofia I.; Förster, Daniel W.; et al.; Tracking Chromosomal Origins in the Northern Italy System of Metacentric Races of the House Mouse; Karger; Cytogenetic And Genome Research; 162; 4; 12-2022; 214-230
dc.identifier.issn
1424-8581
dc.identifier.uri
http://hdl.handle.net/11336/219425
dc.description.abstract
The Western European house mouse is chromosomally diverse, with diploid karyotypes ranging from the standard 40 telocentric chromosomes down to 22 chromosomes. Karyotypes are modified through Robertsonian (Rb) fusion of 2 telocentrics into a single metacentric, occurring repeatedly with fixation, and whole-arm reciprocal translocations (WARTs) generating additional novel karyotypes. Over 100 metacentric populations (chromosomal races) have been identified, geographically clustered into "systems."Chromosomal races within systems often hybridise, and new races may emerge through this hybridisation ("zonal raciation"). We wished to determine the degree to which chromosomal races in a system have evolved independently or share common ancestry. Recombination between chromosomes from hybridising chromosomal races can erase the signals associated with a particular metacentric of interest, making inferences challenging. However, reduced recombination near the centromeres of chromosomal race-specific metacentrics makes centromere-adjacent markers ideal for solving this problem. For the Northern Italy System (NIS), we used microsatellite markers near the centromere to test previous hypotheses about evolutionary relationships of 5 chromosomal races. We chose markers from chromosomes 1, 3, 4, and 6, all of which comprise one arm of a metacentric in at least 2 of these NIS metacentric populations. We used estimates of FST and RST, as well as principal components analyses and neighbour-joining phylogenetic analyses, to infer evolutionary relationships between these 5 chromosomal races and neighbouring mice with the standard karyotype. We showed that the metacentric populations form a single grouping distinct from the standard populations, consistent with their common origin and consistent with a parsimonious sequence of chromosomal rearrangements to explain the relationship of the chromosomal races. That origin and evolution of the chromosomal races in the system would have involved Rb fusions, explaining the occurrence of chromosomal races with diploid numbers as low as 22. However, WARTs and zonal raciation have also been inferred, and the rare occurrence of chromosome 1 in different metacentrics in closely related chromosomal races is almost certainly explained by a WART. Our results with centromeric microsatellites are consistent with the above scenarios, illustrating, once again, the value of markers in the centromeric region to test evolutionary hypotheses in house mouse chromosomal systems.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Karger
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dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
MICROSATELLITES
dc.subject
MUS MUSCULUS DOMESTICUS
dc.subject
PHYLOGENETICS
dc.subject
ROBERTSONIAN FUSIONS
dc.subject
WHOLE-ARM RECIPROCAL TRANSLOCATIONS
dc.subject
ZONAL RACIATION
dc.subject.classification
Biología
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dc.subject.classification
Ciencias Biológicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
Tracking Chromosomal Origins in the Northern Italy System of Metacentric Races of the House Mouse
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2023-12-05T13:17:57Z
dc.journal.volume
162
dc.journal.number
4
dc.journal.pagination
214-230
dc.journal.pais
Suiza
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dc.journal.ciudad
Basel
dc.description.fil
Fil: Giménez, Mabel Dionisia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Misiones; Argentina. Dirección Nacional de Instituto de Investigación.Administración Nacional de Laboratorios e Institutos de Salud "Dr. Carlos G. Malbrán"; Argentina. University of York; Reino Unido
dc.description.fil
Fil: Hughes, Jonathan J.. Cornell University; Estados Unidos
dc.description.fil
Fil: Scascitelli, Moira. University of York; Reino Unido. University of British Columbia; Canadá
dc.description.fil
Fil: Gabriel, Sofia I.. University of York; Reino Unido. Universidade de Aveiro; Portugal. Universidade Nova de Lisboa; Portugal
dc.description.fil
Fil: Förster, Daniel W.. Leibniz-Institute for Zoo and Wildlife Research; Alemania. University of York; Reino Unido
dc.description.fil
Fil: Panithanarak, Thadsin. Burapha University; Tailandia. University of York; Reino Unido
dc.description.fil
Fil: Hauffe, Heidi C.. University of York; Reino Unido. Instituto Agrario San Michele all'Adige Fondazione Edmund Mach; Italia
dc.description.fil
Fil: Searle, Jeremy Byron. Cornell University; Estados Unidos. University of York; Reino Unido
dc.journal.title
Cytogenetic And Genome Research
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1159/000527106
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://karger.com/cgr/article-abstract/162/4/214/822012/Tracking-Chromosomal-Origins-in-the-Northern-Italy?redirectedFrom=fulltext
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