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dc.contributor.author
Yip, Terry Cheuk Fung
dc.contributor.author
Vila Gomez, Eduardo
dc.contributor.author
Petta, Salvatore
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Yilmaz, Yusuf
dc.contributor.author
Wong, Grace Lai Hung
dc.contributor.author
Adams, Leon A.
dc.contributor.author
de Lédinghen, Victor
dc.contributor.author
Sookoian, Silvia Cristina
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dc.contributor.author
Wong, Vincent Wai-Sun
dc.date.available
2023-12-04T14:16:41Z
dc.date.issued
2023-01
dc.identifier.citation
Yip, Terry Cheuk Fung; Vila Gomez, Eduardo; Petta, Salvatore; Yilmaz, Yusuf; Wong, Grace Lai Hung; et al.; Geographical similarity and differences in the burden and genetic predisposition of NAFLD; John Wiley & Sons; Hepatology (Baltimore, Md.); 77; 4; 1-2023; 1404-1427
dc.identifier.issn
0270-9139
dc.identifier.uri
http://hdl.handle.net/11336/219187
dc.description.abstract
NAFLD has become a major public health problem for more than 2 decades with a growing prevalence in parallel with the epidemic of obesity and type 2 diabetes (T2D). The disease burden of NAFLD differs across geographical regions and ethnicities. Variations in prevalence of metabolic diseases, extent of urban-rural divide, dietary habits, lifestyles, and the prevalence of NAFLD risk and protective alleles can contribute to such differences. The rise in NAFLD has led to a remarkable increase in the number of cases of cirrhosis, hepatocellular carcinoma, hepatic decompensation, and liver-related mortality related to NAFLD. Moreover, NAFLD is associated with multiple extrahepatic manifestations. Most of them are risk factors for the progression of liver fibrosis and thus worsen the prognosis of NAFLD. All these comorbidities and complications affect the quality of life in subjects with NAFLD. Given the huge and growing size of the population with NAFLD, it is expected that patients, healthcare systems, and the economy will suffer from the ongoing burden related to NAFLD. In this review, we examine the disease burden of NAFLD across geographical areas and ethnicities, together with the distribution of some well-known genetic variants for NAFLD. We also describe some special populations including patients with T2D, lean patients, the pediatric population, and patients with concomitant liver diseases. We discuss extrahepatic outcomes, patient-reported outcomes, and economic burden related to NAFLD.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
John Wiley & Sons
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dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
NAFLD
dc.subject
NASH
dc.subject
GENETICS
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EPIDEMIOLOGY
dc.subject.classification
Gastroenterología y Hepatología
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dc.subject.classification
Medicina Clínica
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Geographical similarity and differences in the burden and genetic predisposition of NAFLD
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2023-12-04T11:39:16Z
dc.journal.volume
77
dc.journal.number
4
dc.journal.pagination
1404-1427
dc.journal.pais
Estados Unidos
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dc.journal.ciudad
New York
dc.description.fil
Fil: Yip, Terry Cheuk Fung. Chinese University Of Hong Kong; Hong Kong
dc.description.fil
Fil: Vila Gomez, Eduardo. Indiana University School Of Medicine; Estados Unidos
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Fil: Petta, Salvatore. Università degli Studi di Palermo; Italia
dc.description.fil
Fil: Yilmaz, Yusuf. Marmara University; Turquía
dc.description.fil
Fil: Wong, Grace Lai Hung. Chinese University Of Hong Kong; Hong Kong
dc.description.fil
Fil: Adams, Leon A.. Sir Charles Gairdner Hospital; Australia
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Fil: de Lédinghen, Victor. Universite de Bordeaux; Francia
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Fil: Sookoian, Silvia Cristina. Universidad Abierta Interamericana. Secretaría de Investigación. Centro de Altos Estudios En Ciencias Humanas y de la Salud - Sede Buenos Aires.; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Wong, Vincent Wai-Sun. Chinese University Of Hong Kong; Hong Kong
dc.journal.title
Hepatology (Baltimore, Md.)
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1002/hep.32774
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