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dc.contributor.author
Huang, Emerald  
dc.contributor.author
Ngo, Mai  
dc.contributor.author
Yee, Stuart  
dc.contributor.author
Held, Laura  
dc.contributor.author
Norman, Keith  
dc.contributor.author
Scremin, A.M. Erika  
dc.contributor.author
Scremin, Oscar Umberto  
dc.date.available
2017-08-04T20:17:43Z  
dc.date.issued
2013-07  
dc.identifier.citation
Huang, Emerald; Ngo, Mai; Yee, Stuart; Held, Laura; Norman, Keith; et al.; Repeated blast exposure alters open field behavior recorded under low illumination; Elsevier Science; Brain Research; 1529; 7-2013; 125-133  
dc.identifier.issn
0006-8993  
dc.identifier.uri
http://hdl.handle.net/11336/21910  
dc.description.abstract
Blast-induced traumatic brain injury (bTBI) can have devastating behavioral consequences. This study was designed to evaluate the behavioral consequences of single or repeated bTBI, as evaluated by an open field (OF) test conducted in near-darkness to avoid confounding effects of illumination and photophobia. Sprague-Dawley rats under isoflurane anesthesia were exposed to a series of 3 sub-lethal blasts into a compressed air-driven blast chamber separated by 2 week intervals (n¼11). Sham controls received anesthesia but without blast exposure (n¼11). OF tests were performed 1 or 7 days after each blast using a computerized video tracking system in near-darkness to monitor spontaneous activity. Spatial and temporal variables calculated for both blast and sham groups were: Distance moved (cm) and time (s) spent in the center or periphery zones of the field, total distance traveled, speed in center and periphery zones, rearing events and non-linear regressions of distance moved and rearing events on time. Results showed that the sham group expressed the expected decrease (habituation) in total distance walked, and distance walked as well as speed in center and periphery in successive exposures to the OF while the blast group did not, a sign of impaired learning. The blast group also walked more and faster and demonstrated more rearing behavior, both considered OF signs of anxiety. These results indicate that OF outcomes of bTBI in animals have resemblance to alterations observed in human subjects with this condition and might be useful in evaluating the response of behavioral outcomes of bTBI to experimental treatments.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Elsevier Science  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/  
dc.subject
Brain Trauma  
dc.subject
Open Field  
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Animal Behavior  
dc.subject
Cognition  
dc.subject.classification
Bioquímica y Biología Molecular  
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Ciencias Biológicas  
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS  
dc.title
Repeated blast exposure alters open field behavior recorded under low illumination  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2017-08-04T13:48:46Z  
dc.journal.volume
1529  
dc.journal.pagination
125-133  
dc.journal.pais
Países Bajos  
dc.journal.ciudad
Amsterdam  
dc.description.fil
Fil: Huang, Emerald. University of California at Los Angeles; Estados Unidos  
dc.description.fil
Fil: Ngo, Mai. University of California at Los Angeles; Estados Unidos  
dc.description.fil
Fil: Yee, Stuart. University of California at Los Angeles; Estados Unidos  
dc.description.fil
Fil: Held, Laura. Veterans Affairs Greater Los Angeles Healthcare System; Estados Unidos  
dc.description.fil
Fil: Norman, Keith. Veterans Affairs Greater Los Angeles Healthcare System; Estados Unidos  
dc.description.fil
Fil: Scremin, A.M. Erika. Veterans Affairs Greater Los Angeles Healthcare System; Estados Unidos. University of California at Los Angeles; Estados Unidos  
dc.description.fil
Fil: Scremin, Oscar Umberto. Veterans Affairs Greater Los Angeles Healthcare System; Estados Unidos. University of California at Los Angeles; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina  
dc.journal.title
Brain Research  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.brainres.2013.06.042  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0006899313009281