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dc.contributor.author
Garcés, María Fernanda
dc.contributor.author
Buell Acosta, Julieth Daniela
dc.contributor.author
Rodríguez Navarro, Haiver Antonio
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Páez Leal, María Carolina
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Maldonado Acosta, Luis Miguel
dc.contributor.author
Peralta Franco, Jhon Jairo
dc.contributor.author
Burgos Cardenas, Álvaro Javier
dc.contributor.author
Ángel Müller, Edith
dc.contributor.author
Parada Baños, Arturo José
dc.contributor.author
Parra Pineda, Mario Orlando
dc.contributor.author
Eslava Schmalbach, Javier
dc.contributor.author
Escobar Sarmiento, Camilo Andrés
dc.contributor.author
Lacunza, Ezequiel
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dc.contributor.author
Caminos Cepeda, Sofia Alexandra
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Castaño, Justo P
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Nogueiras, Rubén
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Dieguez, Carlos
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Ruiz Parra, Ariel Iván
dc.contributor.author
Caminos, Jorge Eduardo
dc.date.available
2023-12-01T12:48:34Z
dc.date.issued
2023-04
dc.identifier.citation
Garcés, María Fernanda; Buell Acosta, Julieth Daniela; Rodríguez Navarro, Haiver Antonio; Páez Leal, María Carolina; Maldonado Acosta, Luis Miguel; et al.; A longitudinal study of free leptin index in pre-eclamptic pregnancies; Wiley Blackwell Publishing, Inc; Journal Of Cellular And Molecular Medicine (print); 27; 8; 4-2023; 1083-1094
dc.identifier.issn
1582-1838
dc.identifier.uri
http://hdl.handle.net/11336/218966
dc.description.abstract
The ratio between circulating levels of leptin and soluble leptin receptor (sOB-R), the free leptin index (FLI), is used as a marker of leptin resistance. Therefore, the aim of our study was to investigate the FLI in mild pre-eclamptic pregnancies in a nested case–control study within a prospective observational study. Circulating levels of leptin and sOB-R levels rise significantly during pregnancy in healthy (p < 0.05) (n = 46) and pre-eclamptic pregnancies (p < 0.05) (n = 20). Serum levels of leptin were significantly higher in pre-eclamptic compared to healthy pregnancies at second and third trimesters of pregnancy (p < 0.05). Additionally, serum levels of sOB-R were significantly lower in pre-eclamptic pregnancies during the second and third trimesters of pregnancy compared to healthy pregnancies (p < 0.05). Moreover, we found that FLI did not vary significantly during pregnancy in healthy women (p > 0.05), while it increases in pre-eclamptic pregnancies (p < 0.05). Indeed, FLI was significantly higher at second and third trimesters of pregnancy in pre-eclamptic compared to healthy pregnancies (p < 0.05). In addition, FLI was significantly higher in the luteal phase compared with the follicular phase of the menstrual cycle in eumenorrheic women (p < 0.05). Receiver operating characteristic (ROC) curve analysis revealed the ability of leptin (AUC = 0.72) and FLI (AUC = 0.67) as a reliable predictor for mild pre-eclampsia during the second trimester of pregnancy. In conclusion, our findings show that FLI were significantly increased in mild pre-eclamptic pregnancies and allowed us to hypothesize that this rise might alter leptin bioavailability and bioactivity which might lead to the sympathetic hyperactivity and the hypertensive disorders during pregnancy.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Wiley Blackwell Publishing, Inc
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/
dc.subject
FREE LEPTIN INDEX
dc.subject
PREGNANCY AND PRE-ECLAMPSIA
dc.subject.classification
Bioquímica y Biología Molecular
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dc.subject.classification
Ciencias Biológicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
A longitudinal study of free leptin index in pre-eclamptic pregnancies
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2023-11-28T15:04:54Z
dc.journal.volume
27
dc.journal.number
8
dc.journal.pagination
1083-1094
dc.journal.pais
Reino Unido
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dc.journal.ciudad
Londres
dc.description.fil
Fil: Garcés, María Fernanda. Universidad Nacional de Colombia. Facultad de Medicina; Colombia
dc.description.fil
Fil: Buell Acosta, Julieth Daniela. Universidad Nacional de Colombia. Facultad de Medicina; Colombia
dc.description.fil
Fil: Rodríguez Navarro, Haiver Antonio. Universidad Nacional de Colombia. Facultad de Medicina; Colombia
dc.description.fil
Fil: Páez Leal, María Carolina. Universidad Nacional de Colombia. Facultad de Medicina; Colombia
dc.description.fil
Fil: Maldonado Acosta, Luis Miguel. Universidad Nacional de Colombia. Facultad de Medicina; Colombia
dc.description.fil
Fil: Peralta Franco, Jhon Jairo. Universidad Nacional de Colombia. Facultad de Medicina; Colombia
dc.description.fil
Fil: Burgos Cardenas, Álvaro Javier. Universidad Nacional de Colombia. Facultad de Medicina; Colombia
dc.description.fil
Fil: Ángel Müller, Edith. Universidad Nacional de Colombia. Facultad de Medicina; Colombia
dc.description.fil
Fil: Parada Baños, Arturo José. Universidad Nacional de Colombia. Facultad de Medicina; Colombia
dc.description.fil
Fil: Parra Pineda, Mario Orlando. Universidad Nacional de Colombia. Facultad de Medicina; Colombia
dc.description.fil
Fil: Eslava Schmalbach, Javier. Universidad Nacional de Colombia. Facultad de Medicina; Colombia
dc.description.fil
Fil: Escobar Sarmiento, Camilo Andrés. Fundación Sueño Vigilia Colombiana; Colombia
dc.description.fil
Fil: Lacunza, Ezequiel. Universidad Nacional de La Plata. Facultad de Ciencias Médicas. Centro de Investigaciones Inmunológicas Básicas y Aplicadas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
dc.description.fil
Fil: Caminos Cepeda, Sofia Alexandra. Universitat Pompeu Fabra; España
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Fil: Castaño, Justo P. Universidad de Córdoba; España
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Fil: Nogueiras, Rubén. Universidad de Santiago de Compostela; España
dc.description.fil
Fil: Dieguez, Carlos. Instituto de Salud Carlos Iii (isciii);
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Fil: Ruiz Parra, Ariel Iván. Universidad Nacional de Colombia. Facultad de Medicina; Colombia
dc.description.fil
Fil: Caminos, Jorge Eduardo. Universidad Nacional de Colombia. Facultad de Medicina; Colombia
dc.journal.title
Journal Of Cellular And Molecular Medicine (print)
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/10.1111/jcmm.17707
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1111/jcmm.17707
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