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dc.contributor.author
Guelman, Rodolfo
dc.contributor.author
Sánchez, Ariel
dc.contributor.author
Varsavsky, Mariela
dc.contributor.author
Brun, Lucas Ricardo Martín
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García, María Laura
dc.contributor.author
Sarli, Marcelo
dc.contributor.author
Paula, Rey
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Farias, Vanina
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Zanchetta, María Belén
dc.contributor.author
Giacoia, Evangelina
dc.contributor.author
Salerni, Helena
dc.contributor.author
Maffei, Laura
dc.contributor.author
Premrou, Valeria
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Oliveri, Beatriz
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Brance, María Lorena
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Pavlove, Magdalena
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Karlsbrum, Silvia
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Larroudé, María Silvia
dc.contributor.author
Costanzo, Pablo René
dc.date.available
2023-11-30T13:42:22Z
dc.date.issued
2023-01
dc.identifier.citation
Guelman, Rodolfo; Sánchez, Ariel; Varsavsky, Mariela; Brun, Lucas Ricardo Martín; García, María Laura; et al.; Effect of Teriparatide on Bone Mineral Density and Bone Markers in Real-Life: Argentine Experience; Hindawi Publishing Corporation; International Journal of Endocrinology; 2023; 9355672 ; 1-2023; 1-8
dc.identifier.issn
1687-8337
dc.identifier.uri
http://hdl.handle.net/11336/218895
dc.description.abstract
Purpose. To evaluate the effect of teriparatide (TPTD) on bone mineral density (BMD) and bone markers under clinical practice conditions. To assess whether the results in real-life match those published in clinical trials. Methods. Cross-sectional study of postmenopausal women treated with TPTD for at least 12 months. Results. 264 patients were included in the study. Main characteristics are as follows: age: 68.7 ± 10.2 years, previous fractures: 57.6%, and previously treated with antiresorptive (AR-prior): 79%. All bone turnover markers studied significantly increased after 6 months. CTX and BGP remained high up to 24 months, but total and bone alkaline phosphatase returned to basal values at month 18. There was a significant increase in lumbar spine (LS) BMD after 6 months (+6.2%), with a maximum peak at 24 months (+13%). Femoral neck (FN) and total hip (TH) BMD showed a significant increase later than LS (just at month 12), reaching a maximum peak at month 24 (FN + 7.9% and TH + 5.5%). A significant increase in LS BMD was found from month 6 to month 24 compared to basal in both AR-naïve, and AR-prior patients (+16.7% and +10.5%, respectively), without significant differences between the two groups. Comparable results were found in FN and TH BMD. Main conclusions. As reported in real-life clinical studies, treatment of osteoporotic postmenopausal women with TPTD induced a significant increase in bone turnover markers from month 6 onward and an increase in BMD from months 6-12 with continuous gain up to month 24. The real-life results of our study matched the results of randomized clinical trials. In addition, TPTD induced an increase in BMD, regardless of the previous use of AR.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Hindawi Publishing Corporation
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/
dc.subject
Teriparatide
dc.subject
Bone Mineral Density
dc.subject
Bone Markers
dc.subject
Real-Life
dc.subject.classification
Endocrinología y Metabolismo
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Medicina Clínica
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Effect of Teriparatide on Bone Mineral Density and Bone Markers in Real-Life: Argentine Experience
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2023-11-29T13:21:54Z
dc.identifier.eissn
1687-8345
dc.journal.volume
2023
dc.journal.number
9355672
dc.journal.pagination
1-8
dc.journal.pais
Reino Unido
dc.journal.ciudad
Londres
dc.description.fil
Fil: Guelman, Rodolfo. Hospital Italiano. Instituto Universitario. Escuela de Medicina; Argentina
dc.description.fil
Fil: Sánchez, Ariel. Centro de Endocrinología; Argentina
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Fil: Varsavsky, Mariela. Hospital Italiano. Instituto Universitario. Escuela de Medicina; Argentina
dc.description.fil
Fil: Brun, Lucas Ricardo Martín. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Ósea; Argentina
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Fil: García, María Laura. Sanatorio Julio Méndez; Argentina
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Fil: Sarli, Marcelo. Universidad del Salvador; Argentina
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Fil: Paula, Rey. Universidad del Salvador; Argentina
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Fil: Farias, Vanina. Universidad del Salvador; Argentina
dc.description.fil
Fil: Zanchetta, María Belén. Universidad del Salvador; Argentina
dc.description.fil
Fil: Giacoia, Evangelina. Hospital Nacional Profesor Alejandro Posadas; Argentina
dc.description.fil
Fil: Salerni, Helena. Consultorios de Investigación Clínica Endocrinológica y del Metabolismo Óseo; Argentina
dc.description.fil
Fil: Maffei, Laura. Consultorios Asociados de Endocrinología Dra. Laura Maffei; Argentina
dc.description.fil
Fil: Premrou, Valeria. Consultorios Asociados de Endocrinología Dra. Laura Maffei; Argentina
dc.description.fil
Fil: Oliveri, Beatriz. Mautalen Salud E Investigación; Argentina
dc.description.fil
Fil: Brance, María Lorena. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina. Reumatología y Enfermedades Óseas; Argentina
dc.description.fil
Fil: Pavlove, Magdalena. Gobierno de la Ciudad Autónoma de Buenos Aires. Hospital General de Agudos Carlos Durand; Argentina
dc.description.fil
Fil: Karlsbrum, Silvia. Gobierno de la Ciudad Autónoma de Buenos Aires. Hospital General de Agudos Carlos Durand; Argentina
dc.description.fil
Fil: Larroudé, María Silvia. Centro Rossi; Argentina
dc.description.fil
Fil: Costanzo, Pablo René. Hospital Italiano. Instituto Universitario. Escuela de Medicina; Argentina
dc.journal.title
International Journal of Endocrinology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1155/2023/9355672
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.hindawi.com/journals/ije/2023/9355672/
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