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dc.contributor.author
Gasparyan, Ani
dc.contributor.author
Navarro, Daniela
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Navarrete, Francisco
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Austrich Olivares, Amaya
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Scoma, Ernest R.
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Hambardikar, Vedangi D.
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Acosta, Gabriela Beatriz
dc.contributor.author
Solesio, María E.
dc.contributor.author
Manzanares, Jorge
dc.date.available
2023-11-28T19:34:21Z
dc.date.issued
2023-02
dc.identifier.citation
Gasparyan, Ani; Navarro, Daniela; Navarrete, Francisco; Austrich Olivares, Amaya; Scoma, Ernest R.; et al.; Cannabidiol repairs behavioral and brain disturbances in a model of fetal alcohol spectrum disorder; Academic Press Ltd - Elsevier Science Ltd; Pharmacological Research; 188; 2-2023; 1-21
dc.identifier.issn
1043-6618
dc.identifier.uri
http://hdl.handle.net/11336/218759
dc.description.abstract
Fetal alcohol spectrum disorder (FASD) includes neuropsychiatric disturbances related to gestational and lactational ethanol exposure. Available treatments are minimal and do not modulate ethanol-induced damage. Developing animal models simulating FASD is essential for understanding the underlying brain alterations and searching for efficient therapeutic approaches. The main goal of this study was to evaluate the effects of early and chronic cannabidiol (CBD) administration on offspring exposed to an animal model of FASD. Ethanol gavage (3 g/kg/12 h, p.o.) was administered to C57BL/6 J female mice, with a previous history of alcohol consumption, between gestational day 7 and postnatal day 21. On the weaning day, pups were separated by sex, and CBD administration began (30 mg/kg/day, i.p.). After 4–6 weeks of treatment, behavioral and neurobiological changes were analyzed. Mice exposed to the animal model of FASD showed higher anxiogenic and depressive-like behaviors and cognitive impairment that were evaluated through several experimental tests. These behaviors were accompanied by alterations in the gene, cellular and metabolomic targets. CBD administration normalized FASD model-induced emotional and cognitive disturbances, gene expression, and cellular changes with sex-dependent differences. CBD modulates the metabolomic changes detected in the hippocampus and prefrontal cortex. Interestingly, no changes were found in mitochondria or the oxidative status of the cells. These results suggest that the early and repeated administration of CBD modulated the long-lasting behavioral, gene and protein alterations induced by the FASD model, encouraging the possibility of performing clinical trials to evaluate the effects of CBD in children affected with FASD.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Academic Press Ltd - Elsevier Science Ltd
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
ANIMAL MODEL
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CANNABIDIOL
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FASD
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GENE EXPRESSION
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IMMUNOHISTOCHEMISTRY
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METABOLOMIC ANALYSES
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Otras Ciencias de la Salud
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Ciencias de la Salud
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Cannabidiol repairs behavioral and brain disturbances in a model of fetal alcohol spectrum disorder
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2023-11-17T16:27:58Z
dc.journal.volume
188
dc.journal.pagination
1-21
dc.journal.pais
Estados Unidos
dc.description.fil
Fil: Gasparyan, Ani. Universidad de Miguel Hernández; España. Instituto de Salud Carlos III; España. Instituto de Investigación Sanitaria y Biomédica de Alicante; España
dc.description.fil
Fil: Navarro, Daniela. Universidad de Miguel Hernández; España. Instituto de Salud Carlos III; España. Instituto de Investigación Sanitaria y Biomédica de Alicante; España
dc.description.fil
Fil: Navarrete, Francisco. Universidad de Miguel Hernández; España. Instituto de Salud Carlos III; España. Instituto de Investigación Sanitaria y Biomédica de Alicante; España
dc.description.fil
Fil: Austrich Olivares, Amaya. Universidad de Miguel Hernández; España
dc.description.fil
Fil: Scoma, Ernest R.. Rutgers University; Estados Unidos
dc.description.fil
Fil: Hambardikar, Vedangi D.. Rutgers University; Estados Unidos
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Fil: Acosta, Gabriela Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; Argentina
dc.description.fil
Fil: Solesio, María E.. Rutgers University; Estados Unidos
dc.description.fil
Fil: Manzanares, Jorge. Universidad de Miguel Hernández; España. Instituto de Salud Carlos III; España. Instituto de Investigación Sanitaria y Biomédica de Alicante; España
dc.journal.title
Pharmacological Research
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1043661823000117
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1016/j.phrs.2023.106655
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