Artículo
Light-Activated Antibacterial Polymeric Surface Based on Porphycene
Gonzalez Lopez, Edwin Javier
; Renfige Rodriguez, Yone Melisa
; Santamarina, Sofia Carla
; Macor, Lorena Paola
; Otero, Luis Alberto
; Gervaldo, Miguel Andres
; Durantini, Andres Matías
; Durantini, Edgardo Néstor
; Durantini, Javier Esteban
; Heredia, Daniel Alejandro
Fecha de publicación:
02/2023
Editorial:
American Chemical Society
Revista:
ACS Applied Polymer Materials
ISSN:
2637-6105
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
A photoactivatable antimicrobial polymeric surface based on a porphycene derivate was efficiently prepared and evaluated to kill pathogenic microorganisms. The development of this self-sterilizing material consisted in the electrochemical polymerization of a peripherally tetra-substituted porphycene bearing benzyl-carbazole groups (Pc-Cbz). The latter were used as electropolymerizable centers, while the porphycene core triggered the photodynamic action. The electrodeposited photodynamic films (P-Pc-Cbz) were obtained in a reproducible and controllable manner. Electrochemistry studies combined with spectroscopic measurements demonstrated that the porphycene core remains unaffected after the electrodeposition process. Moreover, it retains its spectroscopic and photodynamic properties within the polymeric matrix. The photoactive layers were photostable and able to produce reactive oxygen species (ROS) by both photodynamic mechanisms. Also, the antimicrobial efficiency of P-Pc-Cbz was evaluated against two antibiotic-resistant strains (methicillin-resistant Staphylococcus aureus and Escherichia coli), exhibiting an antimicrobial action higher than 99.998% over these Gram-positive and Gram-negative bacteria. This work represents the first electropolymerization of a porphycene derivative and the first porphycene-based photobiocidal surface. P-Pc-Cbz shows great potential as an efficient self-sterilizing coating activated by visible light.
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Articulos (IDAS)
Articulos de INSTITUTO PARA EL DESARROLLO AGROINDUSTRIAL Y DE LA SALUD
Articulos de INSTITUTO PARA EL DESARROLLO AGROINDUSTRIAL Y DE LA SALUD
Articulos (IITEMA)
Articulos de INSTITUTO DE INVESTIGACIONES EN TECNOLOGIAS ENERGETICAS Y MATERIALES AVANZADOS
Articulos de INSTITUTO DE INVESTIGACIONES EN TECNOLOGIAS ENERGETICAS Y MATERIALES AVANZADOS
Citación
Gonzalez Lopez, Edwin Javier; Renfige Rodriguez, Yone Melisa; Santamarina, Sofia Carla; Macor, Lorena Paola; Otero, Luis Alberto; et al.; Light-Activated Antibacterial Polymeric Surface Based on Porphycene; American Chemical Society; ACS Applied Polymer Materials; 5; 2-2023; 943-956
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