Artículo
Bioadhesive eutectogels supporting drug nanocrystals for long-acting delivery to mucosal tissues
Bianchi, María Beatrice; Zhang, Chunyang; Catlin, Elise; Sandri, Giuseppina; Calderón, Marcelo; Larrañeta, Eneko; Donnelly, Ryan F.; Picchio, Matías Luis
; Paredes, Alejandro Javier
![Icon](/themes/CONICETDigital/images/conicet.png)
![Icon](/themes/CONICETDigital/images/conicet.png)
Fecha de publicación:
12/2022
Editorial:
Elsevier
Revista:
Materials Today Bio
e-ISSN:
2590-0064
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Eutectogels (Egels) are an emerging class of soft ionic materials outperforming traditional temperature-intolerant hydrogels and costly ionogels. Due to their excellent elasticity, non-volatile nature, and adhesion properties, Egels are attracting a great deal of interest in the biomedical space. Herein, we report the first example of adhesive Egels loading drug nanocrystals (Egel-NCs) for controlled delivery to mucosal tissues. These soft materials were prepared using gelatin, glycerine, a deep eutectic solvent (DES) based on choline hydrochloride and glycerol, and nanocrystallised curcumin, a model drug with potent antimicrobial and anti-inflammatory activities. We first explored the impact of the biopolymer concentration on the viscoelastic and mechanical properties of the networks. Thanks to the dynamic interactions between gelatin and the DES, the Egel showed excellent stretchability and elasticity (up to ≈160%), reversible gel-sol phase transition at mild temperature (≈50 °C), 3D-printing ability, and good adhesion to mucin protein (stickiness ≈40 kPa). In vitro release profiles demonstrated the ability of the NCs-based Egel to deliver curcumin for up to four weeks and deposit significantly higher drug amounts in excised porcine mucosa compared to the control cohort. All in all, this study opens new prospects in designing soft adhesive materials for long-acting drug delivery and paves the way to explore novel eutectic systems with multiple therapeutic applications.
Palabras clave:
3D PRINTING
,
BIOADHESION
,
CURCUMIN
,
DRUG DELIVERY
,
EUTECTOGELS
,
NANOCRYSTALS
Archivos asociados
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Identificadores
Colecciones
Articulos(INTEC)
Articulos de INST.DE DES.TECNOL.PARA LA IND.QUIMICA (I)
Articulos de INST.DE DES.TECNOL.PARA LA IND.QUIMICA (I)
Citación
Bianchi, María Beatrice; Zhang, Chunyang; Catlin, Elise; Sandri, Giuseppina; Calderón, Marcelo; et al.; Bioadhesive eutectogels supporting drug nanocrystals for long-acting delivery to mucosal tissues; Elsevier; Materials Today Bio; 17; 100471; 12-2022; 1-13
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