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dc.contributor.author
de Almeida, Liz María
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Cortés, Sandra
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Vilensky, Marta
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Valenzuela, Olivia
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Cortes Sanabria, Laura
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de Souza, Mirian
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Barbeito, Rafael Alonso
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Abdelhay, Eliana
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Artagaveytia, Nora
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Daneri Navarro, Adrian
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Llera, Andrea Sabina
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Müller, Bettina
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Podhajcer, Osvaldo Luis
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Velazquez, Carlos
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Alcoba, Elsa
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Alonso, Isabel
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Bravo, Alicia I.
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Camejo, Natalia
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Carraro, Dirce Maria
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Castro, Mónica
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Cataldi, Sandra
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Cayota, Alfonso
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Cerda, Mauricio
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Colombo, Alicia
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Crocamo, Susanne
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Silva-Garcia, Aida A.
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Viña, Stella
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Zagame, Livia
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Jones, Beth
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Szklo, Moysés
dc.date.available
2023-11-22T14:31:22Z
dc.date.issued
2022-03
dc.identifier.citation
de Almeida, Liz María; Cortés, Sandra; Vilensky, Marta; Valenzuela, Olivia; Cortes Sanabria, Laura; et al.; Socioeconomic, Clinical, and Molecular Features of Breast Cancer Influence Overall Survival of Latin American Women; Frontiers Media; Frontiers in Oncology; 12; 845527; 3-2022; 1-15
dc.identifier.uri
http://hdl.handle.net/11336/218486
dc.description.abstract
Molecular profile of breast cancer in Latin-American women was studied in five countries: Argentina, Brazil, Chile, Mexico, and Uruguay. Data about socioeconomic characteristics, risk factors, prognostic factors, and molecular subtypes were described, and the 60- month overall cumulative survival probabilities (OS) were estimated. From 2011 to 2013, 1,300 eligible Latin-American women 18 years or older, with a diagnosis of breast cancer in clinical stage II or III, and performance status ≦̸ 1 were invited to participate in a prospective cohort study. Face-to-face interviews were conducted, and clinical and outcome data, including death, were extracted from medical records. Unadjusted associations were evaluated by Chi-squared and Fisher’s exact tests and the OS by Kaplan–Meier method. Log-rank test was used to determine differences between cumulative probability curves. Multivariable adjustment was carried out by entering potential confounders in the Cox regression model. The OS at 60 months was 83.9%. Multivariable-adjusted death hazard differences were found for women living in Argentina (2.27), Chile (1.95), and Uruguay (2.42) compared with Mexican women, for older (≥60 years) (1.84) compared with younger (≤40 years) women, for basal-like subtype (5.8), luminal B (2.43), and HER2-enriched (2.52) compared with luminal A subtype, and for tumor clinical stages IIB (1.91), IIIA (3.54), and IIIB (3.94) compared with stage IIA women. OS was associated with country of residence, PAM50 intrinsic subtype, age, and tumor stage at diagnosis. While the latter is known to be influenced by access to care, including cancer screening, timely diagnosis and treatment, including access to more effective treatment protocols, it may also influence epigenetic changes that, potentially, impact molecular subtypes. Data derived from heretofore understudied populations with unique geographic ancestry and sociocultural experiences are critical to furthering our understanding of this complexity.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Frontiers Media
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
BREAST CANCER
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GLOBAL EXCELLENCE
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LATIN AMERICA
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MOLECULAR SUBTYPES
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ONCOLOGY
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PROGNOSIS
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RISK FACTORS
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Ciencias de la Información y Bioinformática
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Ciencias de la Computación e Información
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CIENCIAS NATURALES Y EXACTAS
dc.title
Socioeconomic, Clinical, and Molecular Features of Breast Cancer Influence Overall Survival of Latin American Women
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2023-10-26T15:10:37Z
dc.identifier.eissn
2234-943X
dc.journal.volume
12
dc.journal.number
845527
dc.journal.pagination
1-15
dc.journal.pais
Suiza
dc.journal.ciudad
lousana
dc.description.fil
Fil: de Almeida, Liz María. Instituto Nacional de Câncer; Brasil
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Fil: Cortés, Sandra. Pontificia Universidad Católica de Chile; Chile
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Fil: Vilensky, Marta. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; Argentina
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Fil: Valenzuela, Olivia. Universidad de Sonora; México
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Fil: Cortes Sanabria, Laura. Hospital de Especialidades Centro Medico Nacional Siglo XXI; México
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Fil: de Souza, Mirian. Instituto Nacional de Câncer; Brasil
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Fil: Barbeito, Rafael Alonso. Universidad de la República; Uruguay
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Fil: Abdelhay, Eliana. Instituto Nacional de Câncer; Brasil
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Fil: Artagaveytia, Nora. Universidad de la Republica; Uruguay
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Fil: Daneri Navarro, Adrian. Universidad de Guadalajara; México
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Fil: Llera, Andrea Sabina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
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Fil: Müller, Bettina. Instituto Nacional del Cáncer; Chile
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Fil: Podhajcer, Osvaldo Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
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Fil: Velazquez, Carlos. Universidad de Sonora; México
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Fil: Alcoba, Elsa. Hospital Maria Curie; Argentina
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Fil: Alonso, Isabel. Centro Hospitalario Pereira Rossell; Uruguay
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Fil: Bravo, Alicia I.. Hospital Higa Eva Perón; Argentina
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Fil: Camejo, Natalia. Universidad de la República; Uruguay
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Fil: Carraro, Dirce Maria. A. C. Camargo Cancer Center; Brasil
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Fil: Castro, Mónica. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; Argentina
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Fil: Cataldi, Sandra. Instituto Nacional del Cáncer; Uruguay
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Fil: Cayota, Alfonso. Instituto Pasteur de Montevideo; Uruguay
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Fil: Cerda, Mauricio. Universidad de Chile; Chile
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Fil: Colombo, Alicia. Universidad de Chile; Chile
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Fil: Crocamo, Susanne. Instituto Nacional de Câncer; Brasil
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Fil: Silva-Garcia, Aida A.. Universidad de Guadalajara; México
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Fil: Viña, Stella. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; Argentina
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Fil: Zagame, Livia. Instituto Jalisciense de Cancerología; México
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Fil: Jones, Beth. University of Yale; Estados Unidos
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Fil: Szklo, Moysés. University Johns Hopkins; Estados Unidos
dc.journal.title
Frontiers in Oncology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fonc.2022.845527/full
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3389/fonc.2022.845527
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