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dc.contributor.author
Garcés, Maria Fernanda
dc.contributor.author
Buell Acosta, Julieth Daniela
dc.contributor.author
Ángel Müller, Edith
dc.contributor.author
Parada Baños, Arturo José
dc.contributor.author
Acosta Alvarez, Jaidy
dc.contributor.author
Saavedra López, Harold Felipe
dc.contributor.author
Franco Vega, Roberto
dc.contributor.author
Maldonado Acosta, Luis Miguel
dc.contributor.author
Escobar Cordoba, Franklin
dc.contributor.author
Vásquez Romero, Keydy
dc.contributor.author
Lacunza, Ezequiel
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dc.contributor.author
Caminos Cepeda, Sofía Alexandra
dc.contributor.author
Nogueiras, Rubén
dc.contributor.author
Diéguez, Carlos
dc.contributor.author
Ruiz Parra, Ariel Iván
dc.contributor.author
Caminos, Jorge Eduardo
dc.date.available
2023-11-17T14:53:47Z
dc.date.issued
2022-09
dc.identifier.citation
Garcés, Maria Fernanda; Buell Acosta, Julieth Daniela; Ángel Müller, Edith; Parada Baños, Arturo José; Acosta Alvarez, Jaidy; et al.; Study of the ghrelin/LEAP-2 ratio in humans and rats during different phases of pregnancy; Multidisciplinary Digital Publishing Institute; International Journal of Molecular Sciences; 23; 17; 9-2022; 1-12
dc.identifier.issn
1661-6596
dc.identifier.uri
http://hdl.handle.net/11336/218370
dc.description.abstract
The Liver-Expressed Antimicrobial Peptide 2 (LEAP-2) has emerged as an endogenous GHS-R antagonist and blunts the orexigenic action of ghrelin. This study aimed to determine the Ghrelin/LEAP-2 ratio in humans and rats during pregnancy. In humans, we conducted a nested case-control study within an observational prospective cohort. Healthy and mild preeclamptic pregnant women were studied at each trimester of gestation and three months postpartum. In addition, a group of non-pregnant women was studied into the follicular and luteal phases of the menstrual cycle. Furthermore, Ghrelin/LEAP-2 ratio was investigated in non-pregnant rats and at different periods of rat pregnancy. Human and rat serum ghrelin and LEAP-2 levels were determined using the commercially available ELISA kits. The Ghrelin/LEAP-2 ratio peak around the second trimester of gestation in healthy pregnant women (p < 0.05). Additionally, there were no statistically significant differences in Ghrelin/LEAP-2 ratio between healthy and preeclamptic pregnant women at each trimester of gestation (p > 0.05). The Ghrelin/LEAP-2 ratio in pregnant rat reached the peak around mid-gestation with a similar pattern to the human pregnancy. LEAP-2 was visualized by immunohistochemistry in human term placenta and rat placentas on days 12, 16 and 21 of pregnancy. In conclusion, this study provides the first evidence of a Ghrelin/LEAP-2 ratio peak around the half-way point of pregnancy onwards during human and rat pregnancy, and it might be associated with increased rates of weight gain during pregnancy. Thus, this study suggests that LEAP-2 and Ghrelin/LEAP-2 ratio might play an important role in maternal physiology adaptation of weight gain during pregnancy.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Multidisciplinary Digital Publishing Institute
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/
dc.subject
ENDOGENOUS GHSR ANTAGONIST
dc.subject
GHRELIN/LEAP-2 RATIO
dc.subject
PREGNANCY
dc.subject.classification
Bioquímica y Biología Molecular
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dc.subject.classification
Ciencias Biológicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
Study of the ghrelin/LEAP-2 ratio in humans and rats during different phases of pregnancy
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2023-11-14T14:29:58Z
dc.identifier.eissn
1422-0067
dc.journal.volume
23
dc.journal.number
17
dc.journal.pagination
1-12
dc.journal.pais
Suiza
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dc.description.fil
Fil: Garcés, Maria Fernanda. Universidad Nacional de Colombia; Colombia
dc.description.fil
Fil: Buell Acosta, Julieth Daniela. Universidad Nacional de Colombia; Colombia
dc.description.fil
Fil: Ángel Müller, Edith. Universidad Nacional de Colombia; Colombia
dc.description.fil
Fil: Parada Baños, Arturo José. Universidad Nacional de Colombia; Colombia
dc.description.fil
Fil: Acosta Alvarez, Jaidy. Universidad Nacional de Colombia; Colombia
dc.description.fil
Fil: Saavedra López, Harold Felipe. Universidad Nacional de Colombia; Colombia
dc.description.fil
Fil: Franco Vega, Roberto. Universidad Nacional de Colombia; Colombia
dc.description.fil
Fil: Maldonado Acosta, Luis Miguel. Universidad Nacional de Colombia; Colombia
dc.description.fil
Fil: Escobar Cordoba, Franklin. Universidad Nacional de Colombia; Colombia
dc.description.fil
Fil: Vásquez Romero, Keydy. Universidad de los Andes; Colombia
dc.description.fil
Fil: Lacunza, Ezequiel. Universidad Nacional de La Plata. Facultad de Ciencias Médicas. Centro de Investigaciones Inmunológicas Básicas y Aplicadas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
dc.description.fil
Fil: Caminos Cepeda, Sofía Alexandra. Universitat Pompeu Fabra; España
dc.description.fil
Fil: Nogueiras, Rubén. Universidad de Santiago de Compostela; España
dc.description.fil
Fil: Diéguez, Carlos. Universidad de Santiago de Compostela; España
dc.description.fil
Fil: Ruiz Parra, Ariel Iván. Universidad Nacional de Colombia; Colombia
dc.description.fil
Fil: Caminos, Jorge Eduardo. Universidad Nacional de Colombia; Colombia
dc.journal.title
International Journal of Molecular Sciences
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3390/ijms23179514
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/1422-0067/23/17/9514
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