Mostrar el registro sencillo del ítem
dc.contributor.author
Rivera, Rocío Melissa
dc.contributor.author
Goldkamp, Anna Katherine
dc.contributor.author
Patel, Bhaumik Narendrabhai
dc.contributor.author
Hagen, Darren Erich
dc.contributor.author
Soto Moreno, Edgar Joel
dc.contributor.author
Li, Yahan
dc.contributor.author
Kim, Chris Nayoon
dc.contributor.author
Miller, Cliff
dc.contributor.author
Williams, Fred
dc.contributor.author
Jannaman, Elizabeth
dc.contributor.author
Xiao, Yao
dc.contributor.author
Tribulo, Paula
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.contributor.author
Estrada-Cortés, Eliab
dc.contributor.author
Brau Rodríguez, Astrid Roshealy
dc.contributor.author
Hansen, Peter James
dc.contributor.author
Wu, Zhoulin
dc.contributor.author
Spinka, Christine Marie
dc.contributor.author
Martin, Neal
dc.contributor.author
Elsik, Christine G.
dc.date.available
2023-11-15T19:02:51Z
dc.date.issued
2022-12
dc.identifier.citation
Rivera, Rocío Melissa; Goldkamp, Anna Katherine; Patel, Bhaumik Narendrabhai; Hagen, Darren Erich; Soto Moreno, Edgar Joel; et al.; Identification of large offspring syndrome during pregnancy through ultrasonography and maternal blood transcriptome analyses; Nature; Scientific Reports; 12; 1; 12-2022; 1-16
dc.identifier.uri
http://hdl.handle.net/11336/218251
dc.description.abstract
In vitro production (IVP) of embryos in cattle can result in large/abnormal offspring syndrome (LOS/AOS) which is characterized by macrosomia. LOS can cause dystocia and lead to the death of dam and calf. Currently, no test exists to identify LOS pregnancies. We hypothesized that fetal ultrasonography and/or maternal blood markers are useful to identify LOS. Bovine fetuses were generated by artificial insemination (control) or IVP. Fetal ultrasonographies were taken on gestation D55 (D55) and fetal collections performed on D56 or D105 (gestation in cattle ≈ D280). IVP fetuses weighing ≥ 97 percentile of the control weight were considered LOS. Ultrasonography results show that the product of six D55 measurements can be used to identify extreme cases of LOS. To determine whether maternal blood can be used to identify LOS, leukocyte mRNA from 23 females was sequenced. Unsupervised hierarchical clustering grouped the transcriptomes of the two females carrying the two largest LOS fetuses. Comparison of the leukocyte transcriptomes of these two females to the transcriptome of all other females identified several misregulated transcripts on gestation D55 and D105 with LOC783838 and PCDH1 being misregulated at both time-points. Together our data suggest that LOS is identifiable during pregnancy in cattle.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Nature
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/
dc.subject
Large offspring
dc.subject
Maternal fetal communication
dc.subject
Transcriptome
dc.subject
Fetal development
dc.subject.classification
Producción Animal y Lechería
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.subject.classification
Producción Animal y Lechería
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.subject.classification
CIENCIAS AGRÍCOLAS
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.title
Identification of large offspring syndrome during pregnancy through ultrasonography and maternal blood transcriptome analyses
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2023-11-15T15:53:53Z
dc.identifier.eissn
2045-2322
dc.journal.volume
12
dc.journal.number
1
dc.journal.pagination
1-16
dc.journal.pais
Reino Unido
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.journal.ciudad
Londres
dc.description.fil
Fil: Rivera, Rocío Melissa. University of Missouri; Estados Unidos
dc.description.fil
Fil: Goldkamp, Anna Katherine. Oklahoma State University; Estados Unidos
dc.description.fil
Fil: Patel, Bhaumik Narendrabhai. University of Missouri; Estados Unidos
dc.description.fil
Fil: Hagen, Darren Erich. Oklahoma State University; Estados Unidos
dc.description.fil
Fil: Soto Moreno, Edgar Joel. University of Missouri; Estados Unidos
dc.description.fil
Fil: Li, Yahan. University of Missouri; Estados Unidos
dc.description.fil
Fil: Kim, Chris Nayoon. University of Missouri; Estados Unidos
dc.description.fil
Fil: Miller, Cliff. Green Hills Veterinary Clinic; Estados Unidos
dc.description.fil
Fil: Williams, Fred. University of Missouri; Estados Unidos
dc.description.fil
Fil: Jannaman, Elizabeth. University of Florida; Estados Unidos
dc.description.fil
Fil: Xiao, Yao. University of Florida; Estados Unidos
dc.description.fil
Fil: Tribulo, Paula. University of Florida; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Río Cuarto. Facultad de Agronomía y Veterinaria. Departamento de Reproducción Animal; Argentina
dc.description.fil
Fil: Estrada-Cortés, Eliab. University of Florida; Estados Unidos. Instituto Nacional de Investigaciones Forestales, Agricolas y Pecuarias; México
dc.description.fil
Fil: Brau Rodríguez, Astrid Roshealy. University of Missouri; Estados Unidos
dc.description.fil
Fil: Hansen, Peter James. University of Florida; Estados Unidos
dc.description.fil
Fil: Wu, Zhoulin. Chengdu University; China. University of Missouri; Estados Unidos
dc.description.fil
Fil: Spinka, Christine Marie. University of Missouri; Estados Unidos
dc.description.fil
Fil: Martin, Neal. Martin Veterinary Services; Estados Unidos
dc.description.fil
Fil: Elsik, Christine G.. University of Missouri; Estados Unidos
dc.journal.title
Scientific Reports
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1038/s41598-022-14597-w
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/s41598-022-14597-w
Archivos asociados