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dc.contributor.author Chiorazzi, Michael
dc.contributor.author Rui, Lixin
dc.contributor.author Yang, Yandan
dc.contributor.author Ceribelli, Michelle
dc.contributor.author Tishbi, Nima
dc.contributor.author Maurer. Carine W.
dc.contributor.author Ranuncolo, Stella Maris
dc.contributor.author Zhao, Hong
dc.contributor.author Xu, Weihong
dc.contributor.author Chan, Wing-Chung C.
dc.contributor.author Jaffe, Elaine S.
dc.contributor.author Gascoyne, Randy D.
dc.contributor.author Campo, Elias
dc.contributor.author Rossenwald, Andreas
dc.contributor.author Ott, German
dc.contributor.author Delabie, Jan
dc.contributor.author Rimsza, Lisa M.
dc.contributor.author Shaham, Shai
dc.contributor.author Staudt, Louis M.
dc.date.available 2015-09-28T21:05:49Z
dc.date.issued 2013-03
dc.identifier.citation Chiorazzi, Michael; Rui, Lixin; Yang, Yandan; Ceribelli, Michelle; Tishbi, Nima; et al.; Related F-­box proteins control cell death in Caenorhabditis elegans and human lymphoma; National Academy of Sciences; Proceedings of the National Academy of Sciences of The United States of America; 110; 10; 3-2013; 3943-3948
dc.identifier.issn 0027-8424
dc.identifier.uri http://hdl.handle.net/11336/2181
dc.description.abstract Cell death is a common metazoan cell fate, and its inactivation is central to human malignancy. In Caenorhabditis elegans, apoptotic cell death occurs via the activation of the caspase CED-3 following binding of the EGL-1/BH3-only protein to the antiapoptotic CED-9/ BCL2 protein. Here we report a major alternative mechanism for caspase activation in vivo involving the F-box protein DRE-1. DRE-1 functions in parallel to EGL-1, requires CED-9 for activity, and binds to CED-9, suggesting that DRE-1 promotes apoptosis by inactivating CED-9. FBXO10, a human protein related to DRE-1, binds BCL2 and promotes its degradation, thereby initiating cell death. Moreover, some human diffuse large B-cell lymphomas have inactivating mutations in FBXO10 or express FBXO10 at low levels. Our results suggest that DRE-1/FBXO10 is a conserved regulator of apoptosis.
dc.format application/pdf
dc.language.iso eng
dc.publisher National Academy of Sciences
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject Lymphoma
dc.subject B-CELL
dc.subject F-BOX Proteins
dc.subject.classification Oncología
dc.subject.classification Medicina Clínica
dc.subject.classification CIENCIAS MÉDICAS Y DE LA SALUD
dc.title Related F-­box proteins control cell death in Caenorhabditis elegans and human lymphoma
dc.type info:eu-repo/semantics/article
dc.type info:ar-repo/semantics/artículo
dc.type info:eu-repo/semantics/publishedVersion
dc.date.updated 2016-03-30 10:35:44.97925-03
dc.journal.volume 110
dc.journal.number 10
dc.journal.pagination 3943-3948
dc.journal.pais Usa
dc.journal.ciudad Washington
dc.description.fil Fil: Chiorazzi, Michael. The Rockefeller University. Laboratory of Developmental Genetics; Estados Unidos de América;
dc.description.fil Fil: Rui, Lixin. National Cancer Institute. Center for Cancer Research. Metabolism Branch; Estados Unidos de América;
dc.description.fil Fil: Yang, Yandan. National Cancer Institute. Center for Cancer Research. Metabolism Branch; Estados Unidos de América;
dc.description.fil Fil: Ceribelli, Michelle. National Cancer Institute. Center for Cancer Research. Metabolism Branch; Estados Unidos de América;
dc.description.fil Fil: Tishbi, Nima. The Rockefeller University. Laboratory of Developmental Genetics; Estados Unidos de América;
dc.description.fil Fil: Maurer. Carine W.. The Rockefeller University. Laboratory of Developmental Genetics; Estados Unidos de América;
dc.description.fil Fil: Ranuncolo, Stella Maris. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología; Argentina; National Cancer Institute. Center for Cancer Research. Metabolism Branch; Estados Unidos de América; Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina;
dc.description.fil Fil: Zhao, Hong. National Cancer Institute. Center for Cancer Research. Metabolism Branch; Estados Unidos de América;
dc.description.fil Fil: Xu, Weihong. National Cancer Institute. Center for Cancer Research. Metabolism Branch; Estados Unidos de América;
dc.description.fil Fil: Chan, Wing-Chung C.. University of Nebraska. Department of Pathology and Microbiology; Estados Unidos de América;
dc.description.fil Fil: Jaffe, Elaine S.. National Cancer Institute. Center for Cancer Research. Laboratory of Pathology; Estados Unidos de América;
dc.description.fil Fil: Gascoyne, Randy D.. British Columbia Cancer Agency; Canadá;
dc.description.fil Fil: Campo, Elias. Universidad de Barcelona. Hospital Clínico; España;
dc.description.fil Fil: Rossenwald, Andreas. University of Wurzburg. Department of Pathology; Alemania;
dc.description.fil Fil: Ott, German. Robert-Bosch-Krankenhaus and Dr. Margarete Fischer-Bosch Institute for Clinical Pharmacology. Department of Clinical Pathology; Alemania;
dc.description.fil Fil: Delabie, Jan. Oslo University Hospital. Pathology Clinic; Noruega;
dc.description.fil Fil: Rimsza, Lisa M.. University of Arizona. Department of Pathology; Estados Unidos de América; Southwest Oncology Group; Estados Unidos de América;
dc.description.fil Fil: Shaham, Shai. The Rockefeller University. Laboratory of Developmental Genetics; Estados Unidos de América;
dc.description.fil Fil: Staudt, Louis M.. National Cancer Institute. Center for Cancer Research. Metabolism Branch; Estados Unidos de América;
dc.journal.title Proceedings of the National Academy of Sciences of The United States of America
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/url/http://www.pnas.org/content/110/10/3943.abstract
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/doi:10.1073/pnas.1217271110


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info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)