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dc.contributor.author
Chiorazzi, Michael
dc.contributor.author
Rui, Lixin
dc.contributor.author
Yang, Yandan
dc.contributor.author
Ceribelli, Michelle
dc.contributor.author
Tishbi, Nima
dc.contributor.author
Maurer. Carine W.
dc.contributor.author
Ranuncolo, Stella Maris
dc.contributor.author
Zhao, Hong
dc.contributor.author
Xu, Weihong
dc.contributor.author
Chan, Wing-Chung C.
dc.contributor.author
Jaffe, Elaine S.
dc.contributor.author
Gascoyne, Randy D.
dc.contributor.author
Campo, Elias
dc.contributor.author
Rossenwald, Andreas
dc.contributor.author
Ott, German
dc.contributor.author
Delabie, Jan
dc.contributor.author
Rimsza, Lisa M.
dc.contributor.author
Shaham, Shai
dc.contributor.author
Staudt, Louis M.
dc.date.available
2015-09-28T21:05:49Z
dc.date.issued
2013-03
dc.identifier.citation
Chiorazzi, Michael; Rui, Lixin; Yang, Yandan; Ceribelli, Michelle; Tishbi, Nima; et al.; Related F-­box proteins control cell death in Caenorhabditis elegans and human lymphoma; National Academy of Sciences; Proceedings of the National Academy of Sciences of The United States of America; 110; 10; 3-2013; 3943-3948
dc.identifier.issn
0027-8424
dc.identifier.uri
http://hdl.handle.net/11336/2181
dc.description.abstract
Cell death is a common metazoan cell fate, and its inactivation is central to human malignancy. In Caenorhabditis elegans, apoptotic cell death occurs via the activation of the caspase CED-3 following binding of the EGL-1/BH3-only protein to the antiapoptotic CED-9/ BCL2 protein. Here we report a major alternative mechanism for caspase activation in vivo involving the F-box protein DRE-1. DRE-1 functions in parallel to EGL-1, requires CED-9 for activity, and binds to CED-9, suggesting that DRE-1 promotes apoptosis by inactivating CED-9. FBXO10, a human protein related to DRE-1, binds BCL2 and promotes its degradation, thereby initiating cell death. Moreover, some human diffuse large B-cell lymphomas have inactivating mutations in FBXO10 or express FBXO10 at low levels. Our results suggest that DRE-1/FBXO10 is a conserved regulator of apoptosis.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
National Academy of Sciences
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Lymphoma
dc.subject
B-Cell
dc.subject
F-Box Proteins
dc.subject.classification
Oncología
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Medicina Clínica
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Related F-­box proteins control cell death in Caenorhabditis elegans and human lymphoma
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-03-30 10:35:44.97925-03
dc.journal.volume
110
dc.journal.number
10
dc.journal.pagination
3943-3948
dc.journal.pais
Usa
dc.journal.ciudad
Washington
dc.description.fil
Fil: Chiorazzi, Michael. The Rockefeller University. Laboratory of Developmental Genetics; Estados Unidos de América;
dc.description.fil
Fil: Rui, Lixin. National Cancer Institute. Center for Cancer Research. Metabolism Branch; Estados Unidos de América;
dc.description.fil
Fil: Yang, Yandan. National Cancer Institute. Center for Cancer Research. Metabolism Branch; Estados Unidos de América;
dc.description.fil
Fil: Ceribelli, Michelle. National Cancer Institute. Center for Cancer Research. Metabolism Branch; Estados Unidos de América;
dc.description.fil
Fil: Tishbi, Nima. The Rockefeller University. Laboratory of Developmental Genetics; Estados Unidos de América;
dc.description.fil
Fil: Maurer. Carine W.. The Rockefeller University. Laboratory of Developmental Genetics; Estados Unidos de América;
dc.description.fil
Fil: Ranuncolo, Stella Maris. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología; Argentina; National Cancer Institute. Center for Cancer Research. Metabolism Branch; Estados Unidos de América; Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina;
dc.description.fil
Fil: Zhao, Hong. National Cancer Institute. Center for Cancer Research. Metabolism Branch; Estados Unidos de América;
dc.description.fil
Fil: Xu, Weihong. National Cancer Institute. Center for Cancer Research. Metabolism Branch; Estados Unidos de América;
dc.description.fil
Fil: Chan, Wing-Chung C.. University of Nebraska. Department of Pathology and Microbiology; Estados Unidos de América;
dc.description.fil
Fil: Jaffe, Elaine S.. National Cancer Institute. Center for Cancer Research. Laboratory of Pathology; Estados Unidos de América;
dc.description.fil
Fil: Gascoyne, Randy D.. British Columbia Cancer Agency; Canadá;
dc.description.fil
Fil: Campo, Elias. Universidad de Barcelona. Hospital Clínico; España;
dc.description.fil
Fil: Rossenwald, Andreas. University of Wurzburg. Department of Pathology; Alemania;
dc.description.fil
Fil: Ott, German. Robert-Bosch-Krankenhaus and Dr. Margarete Fischer-Bosch Institute for Clinical Pharmacology. Department of Clinical Pathology; Alemania;
dc.description.fil
Fil: Delabie, Jan. Oslo University Hospital. Pathology Clinic; Noruega;
dc.description.fil
Fil: Rimsza, Lisa M.. University of Arizona. Department of Pathology; Estados Unidos de América; Southwest Oncology Group; Estados Unidos de América;
dc.description.fil
Fil: Shaham, Shai. The Rockefeller University. Laboratory of Developmental Genetics; Estados Unidos de América;
dc.description.fil
Fil: Staudt, Louis M.. National Cancer Institute. Center for Cancer Research. Metabolism Branch; Estados Unidos de América;
dc.journal.title
Proceedings of the National Academy of Sciences of The United States of America
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.pnas.org/content/110/10/3943.abstract
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/doi:10.1073/pnas.1217271110


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