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dc.contributor.author
Cavallaro, Valeria
dc.contributor.author
Alza, Natalia Paola
dc.contributor.author
Murray, María Gabriela
dc.contributor.author
Murray, Ana Paula
dc.date.available
2017-08-03T16:05:39Z
dc.date.issued
2014-01
dc.identifier.citation
Cavallaro, Valeria; Alza, Natalia Paola; Murray, María Gabriela; Murray, Ana Paula; Alkaloids from Habranthus tubispathus and H. jamesonii, two amaryllidaceae with aAcetyl- and butyrylcholinesterase inhibition activity; Natural Products; Natural Product Communications; 9; 2; 1-2014; 159-162
dc.identifier.issn
1934-578X
dc.identifier.uri
http://hdl.handle.net/11336/21813
dc.description.abstract
Alzheimer´s disease (AD) is a neurodegenerative disorder associated with memory impairment and cognitive deficit. Most of the drugs currently available for the treatment of AD are acetylcholinesterase (AChE) inhibitors. Plants of the Amaryllidaceae family are known to synthesize alkaloids, which have shown AChE inhibitory activity. Habranthus tubispathus and H. jamesonii are two Amaryllidaceae that can be found growing wild to the southwest of Buenos Aires in Argentina. Acetyl- and butyrylcholinesterase inhibition was observed for the extracts obtained from bulbs of H. tubispathus and bulbs and aerial parts of H. jamesonii. The strongest cholinesterase inhibition was observed for the alkaloid extract obtained from the aerial parts for H. jamesonii (AChE IC50= 0.7 µg/mL; BChE IC50= 6.7 µg/mL). The AChE inhibition observed for H. jamesonii could be explained by the presence of galanthamine and sanguinine, two potent AChE inhibitors. The levels of lycorine and hippeastidine, moderate AChE inhibitors, observed in the bulbs of H. tubispathus could be responsible for the significant AChE inhibition observed. The alkaloids present in these Amaryllidaceae were identified by means of GC-MS analysis. In the case of H. tubispathus, hippeastidine and 3-O-demethylhippeastidine, were isolated and completely characterized by 1H and 13C NMR spectroscopy.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Natural Products
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc/2.5/ar/
dc.subject
Habranthus Tubispathus
dc.subject
Habranthus Jamesonii
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Amaryllidaceae
dc.subject
Acetylcholinesterase Inhibition
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Butyrylcholinesterase Inhibition
dc.subject
Alkaloids
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Otras Ciencias Químicas
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Ciencias Químicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
Alkaloids from Habranthus tubispathus and H. jamesonii, two amaryllidaceae with aAcetyl- and butyrylcholinesterase inhibition activity
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-07-31T21:43:54Z
dc.identifier.eissn
1555-9475
dc.journal.volume
9
dc.journal.number
2
dc.journal.pagination
159-162
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Westerville
dc.description.fil
Fil: Cavallaro, Valeria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina
dc.description.fil
Fil: Alza, Natalia Paola. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina
dc.description.fil
Fil: Murray, María Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Ciencias Biológicas y Biomédicas del Sur. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia. Instituto de Ciencias Biológicas y Biomédicas del Sur; Argentina
dc.description.fil
Fil: Murray, Ana Paula. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina
dc.journal.title
Natural Product Communications
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://journals.sagepub.com/doi/pdf/10.1177/1934578X1400900206
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