Artículo
Tailored multivalent targeting of siglecs with photosensitizing liposome nanocarriers
Almeida Marrero, Verónica; Bethlehem, Fleur; Longo, Sara; Bertolino, María Candelaria
; Torres, Tomás; Huskens, Jurriaan; de la Escosura, Andrés
![Icon](/themes/CONICETDigital/images/conicet.png)
Fecha de publicación:
02/07/2022
Editorial:
Wiley VCH Verlag
Revista:
Angewandte Chemie
ISSN:
1433-7851
e-ISSN:
1521-3773
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
The modification of surfaces with multiple ligands allows the formation of platforms for the study of multivalency in diverse processes. Herein we use this approach for the implementation of a photosensitizer (PS)-nanocarrier system that binds efficiently to siglec-10, a member of the CD33 family of siglecs (sialic acid (SA)-binding immunoglobulin-like lectins). In particular, a zinc phthalocyanine derivative bearing three SA moieties (PcSA) has been incorporated in the membrane of small unilamellar vesicles (SUVs), retaining its photophysical properties upon insertion into the SUV's membrane. The interaction of these biohybrid systems with human siglec-10-displaying supported lipid bilayers (SLBs) has shown the occurrence of weakly multivalent, superselective interactions between vesicle and SLB. The SLB therefore acts as an excellent cell membrane mimic, while the binding with PS-loaded SUVs shows the potential for targeting siglec-expressing cells with photosensitizing nanocarriers.
Palabras clave:
LIPOSOME NANOCARRIERS
,
MULTIVALENCY
,
PHOTOSENSITIZER
,
SIGLECS
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Identificadores
Colecciones
Articulos(INFIQC)
Articulos de INST.DE INVESTIGACIONES EN FISICO- QUIMICA DE CORDOBA
Articulos de INST.DE INVESTIGACIONES EN FISICO- QUIMICA DE CORDOBA
Citación
Almeida Marrero, Verónica; Bethlehem, Fleur; Longo, Sara; Bertolino, María Candelaria; Torres, Tomás; et al.; Tailored multivalent targeting of siglecs with photosensitizing liposome nanocarriers; Wiley VCH Verlag; Angewandte Chemie; 61; 31; 02-7-2022; 1-8
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