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dc.contributor.author
Rodriguez Granillo, Gaston Alfredo
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Toselli, Luzia
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Farina, Juan
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Raggio, Ignacio
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Diluca, Pablo
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Fontana, Lucia
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Valle Anziani, Maxroxia
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Bordoli, Ines
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Bellia-Munzon, Gaston
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Martínez Ferro, Marcelo
dc.date.available
2023-11-14T13:48:53Z
dc.date.issued
2022-10
dc.identifier.citation
Rodriguez Granillo, Gaston Alfredo; Toselli, Luzia; Farina, Juan; Raggio, Ignacio; Diluca, Pablo; et al.; Usefulness of strain cardiac magnetic resonance for the exposure of mild left ventricular systolic abnormalities in pectus excavatum; Elsevier; Journal Of Pediatric Surgery; 57; 10; 10-2022; 319-324
dc.identifier.issn
0022-3468
dc.identifier.uri
http://hdl.handle.net/11336/218019
dc.description.abstract
Background: Systolic dysfunction in pectus excavatum (PEX) is usually very subtle and mainly focused on the right ventricle (RV), leading to normal or unremarkable cardiac imaging findings unless involving exercise stress. Objectives: We evaluated systolic function in PEX using longitudinal strain cardiac magnetic resonance (CMR), a validated parameter for the assessment of the systolic deformation of subendocardial fibers. Methods: This prospective registry comprised consecutive patients with PEX who were referred to CMR to define treatment strategies or to establish surgical candidacy. We also included a control group of 15 healthy volunteers without chest wall abnormalities. Using dedicated software, we evaluated the endocardial global longitudinal strain (GLS) of both ventricles and the endocardial global circumferential strain (GCS) of the left ventricle (LV). Results: A total of 50 patients with PEX comprised the study population, with a mean age of 19.9 ± 8.0 years. The right ventricular ejection fraction (RVEF) of patients with PEX was significantly lower compared to the control group both at end-expiration (59.5 ± 6.8 vs. 64.7 ± 4.7%, p = 0.008) and end-inspiration (56.7 ± 7.2%, vs. 62.7 ± 4.4, p = 0.004); as well as the pulmonary stroke distance (12.6 ± 2.5, vs. 15.0 ± 2.0 cm, p = 0.001). The LV volumetric analysis revealed no differences between PEX and the control group (p > 0.05 for all) regardless of the respiratory cycle, with a mean expiratory LV ejection fraction (LVEF) of 61.4 ± 6.0%. In contrast, the GLS of the LV was significantly lower in PEX compared to controls (-21.2 ± 3.2 vs. -23.7 ± 3.0%, p = 0.010), whereas GCS was similar either at expiration (-28.5 ± 4.0%, vs. -29.5 ± 2.8, p = 0.38) or inspiration (-29.3 ± 4.1%, vs.-28.9 ± 2.3, p = 0.73). Conclusions: In this study, we demonstrated that longitudinal strain analysis might enable the detection of very subtle left ventricular systolic function abnormalities in patients with PEX, that are commonly overlooked using the conventional assessment. Level of evidence: II
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
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FUNNEL CHEST
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MAGNETIC RESONANCE IMAGING
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STRAIN
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Sistemas Cardíaco y Cardiovascular
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Medicina Clínica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Usefulness of strain cardiac magnetic resonance for the exposure of mild left ventricular systolic abnormalities in pectus excavatum
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2023-11-13T10:42:52Z
dc.journal.volume
57
dc.journal.number
10
dc.journal.pagination
319-324
dc.journal.pais
Países Bajos
dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Rodriguez Granillo, Gaston Alfredo. Clinica La Sagrada Familia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto Alberto C. Taquini de Investigaciones en Medicina Traslacional - Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas "Prof. Dr. Alberto C. Taquini". Instituto Alberto C. Taquini de Investigaciones en Medicina Traslacional; Argentina
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Fil: Toselli, Luzia. Fundación Hospitalaria Mother and Child Medical Center; Argentina
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Fil: Farina, Juan. Mayo Clinic Cancer Center; Estados Unidos
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Fil: Raggio, Ignacio. Swiss Medical Group; Argentina. Centro de Educación Médica e Investigaciones Clínicas "Norberto Quirno"; Argentina
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Fil: Diluca, Pablo. Clinica La Sagrada Familia; Argentina
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Fil: Fontana, Lucia. Clinica La Sagrada Familia; Argentina
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Fil: Valle Anziani, Maxroxia. Fundación Hospitalaria Mother and Child Medical Center; Argentina
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Fil: Bordoli, Ines. Clinica La Sagrada Familia; Argentina
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Fil: Bellia-Munzon, Gaston. Fundación Hospitalaria Mother and Child Medical Center; Argentina
dc.description.fil
Fil: Martínez Ferro, Marcelo. Fundación Hospitalaria Mother And Child Medical Center; Argentina
dc.journal.title
Journal Of Pediatric Surgery
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.jpedsurg.2021.09.008
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0022346821006011
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