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dc.contributor.author
Espeche Turbay, Maria Beatriz
dc.contributor.author
de Moreno, Maria Alejandra
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Perdigon, Gabriela del Valle
dc.contributor.author
Savoy, Graciela
dc.contributor.author
Hebert, Elvira Maria
dc.date.available
2017-08-02T21:28:10Z
dc.date.issued
2012-02
dc.identifier.citation
Espeche Turbay, Maria Beatriz; de Moreno, Maria Alejandra; Perdigon, Gabriela del Valle; Savoy, Graciela; Hebert, Elvira Maria; B-casein hydrolysate generated by the cell envelope-associated proteinase of Lactobacillus delbrueckii subsp. lactis CRL 581 protects against trinitrobenzene sulfonic acid-induced colitis in mice; Elsevier; Journal of Dairy Science; 95; 3; 2-2012; 1108-1118
dc.identifier.issn
0022-0302
dc.identifier.uri
http://hdl.handle.net/11336/21786
dc.description.abstract
Lactobacillus delbrueckii subsp. lactis CRL 581, a thermophilic lactic acid bacterium used as a starter culture for the manufacture of several fermented dairy products, possess an efficient proteolytic system which is able to release a series of potentially bioactive peptides (i.e. antihypertensive and phosphopeptides) from alpha- and beta-caseins. Considering the potential beneficial health effects of the peptides released by L. delbrueckii subsp. lactis CRL 581 from milk proteins, the aim of this work was to analyze the antimutagenic and anti-inflammatory properties of the casein hydrolysates generated by the cell envelope-associated proteinase of this bacterium. The ability of alpha- and beta-casein hydrolysates to suppress the mutagenesis of a direct-acting mutagen 4-nitroquinoline-N-oxide on Salmonella typhimurium TA 98 and TA 100 increased concomitantly with the time of casein hydrolysis. The anti-inflammatory effect of the beta-casein hydrolysate was evaluated using a trinitrobenzene sulfonic acid (TNBS) induced Crohn’s disease murine model. The hydrolysate was administered to mice 10 days before the intrarectal inoculation of TNBS. The mice that received B-casein hydrolysate previously to TNBS showed decreased mortality rates, faster recovery of initial body weight loss, lesser microbial translocation to the liver, decreased B-glucuronidase and myeloperoxidase activities in the gut and reduced colonic macroscopic and microscopic damages compared to the animals that did not receive this hydrolysate. In addition, B-casein hydrolysate exerted a beneficial effect on acute intestinal inflammation by increased interleukin 10 and decreased IFN-gamma production in the gut. Our findings demonstrated the health promoting attributes of the milk products fermented by L. delbrueckii subsp. lactis CRL 581 and open up new opportunities for developing novel functional foods.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
Bioactive Peptide
dc.subject
Lactic Acid Bacteria
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Casein Hydrolysate
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Proteinase
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Alimentos y Bebidas
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Otras Ingenierías y Tecnologías
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INGENIERÍAS Y TECNOLOGÍAS
dc.title
B-casein hydrolysate generated by the cell envelope-associated proteinase of Lactobacillus delbrueckii subsp. lactis CRL 581 protects against trinitrobenzene sulfonic acid-induced colitis in mice
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-07-26T15:25:14Z
dc.identifier.eissn
1525-3198
dc.journal.volume
95
dc.journal.number
3
dc.journal.pagination
1108-1118
dc.journal.pais
Países Bajos
dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Espeche Turbay, Maria Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Centro de Referencia Para Lactobacilos; Argentina
dc.description.fil
Fil: de Moreno, Maria Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Centro de Referencia Para Lactobacilos; Argentina
dc.description.fil
Fil: Perdigon, Gabriela del Valle. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Centro de Referencia Para Lactobacilos; Argentina
dc.description.fil
Fil: Savoy, Graciela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Centro de Referencia Para Lactobacilos; Argentina
dc.description.fil
Fil: Hebert, Elvira Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Centro de Referencia Para Lactobacilos; Argentina
dc.journal.title
Journal of Dairy Science
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3168/jds.2011-4735
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0022030212000690
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