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dc.contributor.author
Posadas Martinez, Maria Lourdes  
dc.contributor.author
Aguirre, Maria Adela  
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Brulc, Erika B.  
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Saez, Maria Soledad  
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Sorroche, Patricia Beatriz  
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Machnicki, Gerardo  
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Fernandez, Mariana  
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Nucifora, Elsa Mercedes  
dc.date.available
2023-11-13T12:26:04Z  
dc.date.issued
2022-10  
dc.identifier.citation
Posadas Martinez, Maria Lourdes; Aguirre, Maria Adela; Brulc, Erika B.; Saez, Maria Soledad; Sorroche, Patricia Beatriz; et al.; Treatment patterns and outcomes in light chain amyloidosis: An institutional registry of amyloidosis report in Argentina; Public Library of Science; Plos One; 17; 10-2022; 1-14  
dc.identifier.issn
1932-6203  
dc.identifier.uri
http://hdl.handle.net/11336/217849  
dc.description.abstract
Light chain (AL) amyloidosis is a form of systemic amyloidosis, causing organ dysfunction, mainly affecting the heart and kidney. Patient-tailored and risk-adapted decision making is critical in AL amyloidosis management. There is limited real-world evidence data from Argentina and Latin America regarding the treatment approaches for AL amyloidosis. This retrospective cohort study aimed to describe the treatment patterns and outcomes in adult patients (>18 years) diagnosed with AL amyloidosis at the Hospital Italiano in Buenos Aires, Argentina, using a 10-yearfollow-up data (June 1, 2010 to May 31, 2019) from the institutional registry of amyloidosis (IRA). The study population had a mean age of 63 years and 54.4% weremale. Heart and kidney were the most frequently affected organs. Of the 90 eligible patients included in the study, 70underwent treatment. Bortezomib-based regimen was the preferred first-line treatment (75.7% patients). Overall, 54.4% of the patients presented a deep response (complete or very good partial response). Median overall survival (OS) was 5years, the 1-year OS and progression free survival rates were 80% (95% confidence interval [CI]: 68–87) and 80% (95%CI 68–87)), respectively. This study provides vital real-world evidence for the long-term treatment patterns and survival in a large cohort of AL amyloidosis patients in Argentina.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Public Library of Science  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
LIGHT CHAIN AMYLOIDOSIS  
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TREATMENT PATTERNS  
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AMYLOIDOSIS ARGENTINA  
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Hematología  
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Medicina Clínica  
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CIENCIAS MÉDICAS Y DE LA SALUD  
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Epidemiología  
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Ciencias de la Salud  
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CIENCIAS MÉDICAS Y DE LA SALUD  
dc.title
Treatment patterns and outcomes in light chain amyloidosis: An institutional registry of amyloidosis report in Argentina  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2023-11-10T14:35:11Z  
dc.journal.volume
17  
dc.journal.pagination
1-14  
dc.journal.pais
Estados Unidos  
dc.journal.ciudad
San Francisco  
dc.description.fil
Fil: Posadas Martinez, Maria Lourdes. Hospital Italiano; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina  
dc.description.fil
Fil: Aguirre, Maria Adela. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Medicina Traslacional E Ingenieria Biomedica. - Hospital Italiano. Instituto de Medicina Traslacional E Ingenieria Biomedica. - Instituto Universitario Hospital Italiano de Buenos Aires. Instituto de Medicina Traslacional E Ingenieria Biomedica.; Argentina  
dc.description.fil
Fil: Brulc, Erika B.. Hospital Italiano; Argentina  
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Fil: Saez, Maria Soledad. Hospital Italiano; Argentina  
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Fil: Sorroche, Patricia Beatriz. Hospital Italiano; Argentina  
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Fil: Machnicki, Gerardo. No especifíca;  
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Fil: Fernandez, Mariana. No especifíca;  
dc.description.fil
Fil: Nucifora, Elsa Mercedes. Hospital Italiano; Argentina  
dc.journal.title
Plos One  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1371/journal.pone.0274578